2DUltrashort Echo-Time Functional Lung Imaging
2DUltrashort Echo-Time Functional Lung Imaging
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DOI：
10.1002/jmri.27269
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发表时间：
2020-07-11
影响因子：
4.4
通讯作者：
Rasche, Volker
中科院分区：
文献类型：
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作者：
Balasch, Anke;Metze, Patrick;Rasche, Volker
由于固有的低质子密度和快速的T-2*弛豫，肺部MRI成像具有挑战性。需要提供肺实质和功能的MRI方法。目的探讨二维超短超声时间（2D UTE）成像评价肺功能的可行性。前瞻性研究类型。11名健康志愿者。场强/序列3T， 2D小黄金角UTE （2D- tyute）。研究了屏气（BH）和自门控（SG） 2D-tyUTE定量肺实质信噪比（SNR）、质子分数（f(P)）、分次通气（FV）和灌注(f)的适用性。研究了吸烟者和非吸烟者对重复时间（BHS/I1/I2）和呼吸期（呼气[EX]，吸气[IN]）的依赖关系并进行了比较。统计检验方差分析（ANOVA）， Kendell's W.结果信噪比显著差异(EX: 10.98 +/- 3.19(BHS), 14.58 +/- 3.89(BHI1), 17.59 +/- 4.92(BHI2), 11.00 +/- 5.42(SG)；不同入路的IN分别为7.17 +/- 2.07（BHS）、9.51 +/- 2.37（BHI1）、10.49 +/- 2.33（BHI2）、10.00 +/- 4.14(SG)，差异均有统计学意义（P < 0.05）。其中呼气组的P值（0.41 +/- 0.13）与BH成像技术无关，SG组的P值略高（0.44 +/- 0.06）。在BH技术中FV可重复（0.41 +/- 0.10），而在SG技术中FV可重复（0.21 +/- 0.06）（P < 0.05）。呼吸幅值与FV呈中度相关（R-2= 0.47,P < 0.01）。对照组与对照组灌注分析无显著差异（EX: 3.50 +/- 1.29 mL/min/mL [BHS]; IN: 2.36 +/- 1.05 mL/min/mL [BHS]）。吸烟者（0.48 +/- 0.11 BH）和非吸烟者（0.37 +/- 0.12 BH）之间的过期时间差异有统计学意义(P)。本研究证明了2D-tyUTE在临床有吸引力的采集时间内成功量化3T相关肺功能参数的可行性。在切片选择方向上的低空间分辨率可能会限制最终的灵敏度，需要进一步的临床评估。证据等级2技术功效阶段1
Background Imaging of the lung by MRI is challenging due to the intrinsic low proton density and rapid T-2* relaxation. MRI methods providing lung parenchyma and function are in demand. Purpose To investigate the feasibility of two-dimensional ultrashort echo-time (2D UTE) imaging for lung function assessment. Study Type Prospective. Population Eleven healthy volunteers. Field Strength/Sequence 3T, 2D tiny golden angle UTE (2D-tyUTE). Assessment The applicability of breath-hold (BH) and self-gated (SG) 2D-tyUTE for quantification of the lung parenchyma signal-to-noise ratio (SNR), proton fraction (f(P)), fractional ventilation (FV), and perfusion (f) was investigated. Dependencies on repetition time (BHS/I1/I2) and respiratory phase (expiration [EX], inspiration [IN]) were investigated and compared between smokers and nonsmokers. Statistical Tests Analysis of variance (ANOVA), Kendell's W. Results Significant differences of SNR (EX: 10.98 +/- 3.19(BHS), 14.58 +/- 3.89(BHI1), 17.59 +/- 4.92(BHI2), 11.00 +/- 5.42(SG); IN: 7.17 +/- 2.07(BHS), 9.51 +/- 2.37(BHI1), 10.49 +/- 2.33(BHI2), 10.00 +/- 4.14(SG)) (P < 0.05 for all cases) were observed between the different approaches. Wheref(P)in expiration (0.41 +/- 0.13) was independent of the BH imaging technique, it was slightly higher in SG (0.44 +/- 0.06). FV was reproducible among the BH techniques (0.41 +/- 0.10), but significantly lower in SG (0.21 +/- 0.06) (P < 0.05). A moderate correlation (R-2= 0.47,P < 0.01) was observed between the breathing amplitude and FV. No significant differences between BH and SG were observed for the perfusion analysis (EX: 3.50 +/- 1.29 mL/min/mL [BHS]; IN: 2.36 +/- 1.05 mL/min/mL [BHS]). Significant differences inf(P)were found between smokers (0.48 +/- 0.11 BH) and nonsmokers (0.37 +/- 0.12 BH) in expiration. Data Conclusion This study demonstrates the feasibility of 2D-tyUTE for successful quantification of relevant lung function parameters at 3T within clinically attractive acquisition times. The low spatial resolution into the slice selection direction may limit the final sensitivity and needs further clinical evaluation. Level of Evidence 2 Technical Efficacy Stage 1