Novel priming and crosslinking systems for use with isocyanatomethacrylate dental adhesives
Novel priming and crosslinking systems for use with isocyanatomethacrylate dental adhesives
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DOI：
10.1016/s0109-5641(00)00034-8
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发表时间：
2000-11-01
期刊：
影响因子：
5
通讯作者：
Eick, JD
中科院分区：
文献类型：
--
作者：
Chappelow, CC;Power, MD;Eick, JD
目的：（a）设计、配制和评价用于异氰酸酯基甲基丙烯酸酯共聚单体粘合剂的原型底漆和交联剂，和（B）建立粘合剂和蚀刻牙本质之间的粘结强度和溶解度参数差异与粘合剂的渗透系数之间的相关性。将甲基丙烯酸2-异氰酸酯基乙酯（IEM）和甲基丙烯酸酯共聚单体的等摩尔混合物与三-II-丁基硼烷氧化物（TBBO）一起配制，作为自由基引发剂，固化时间为6-10分钟。使用标准测试方案测定每种粘合剂混合物（n = 7）与牙本质的剪切粘结强度。三个系统的剪切粘结强度也被确定后的应用程序的“反应引物”的牙本质表面。“反应性底漆”含有10-20重量份的相应共聚单体混合物和3.5重量份的TBBO的丙酮溶液。对每种粘合剂系统的溶解度参数差值（Delta Delta）和渗透系数（P）进行近似计算，并与剪切粘合强度值相关。另外，通过含有IEM和甲基丙烯酸酯共聚单体的等摩尔混合物的本体反应制备交联剂。测定了交联剂添加对（a）IEM的凝固时间;和（B）选定的IEM/共聚单体混合物的凝固时间和引发剂要求的影响。（无引物），20.1 +/- 2.0（有引物）; IEM/ETMA 9.3 +/- 3.3（无引物），20.8 +/- 8.1（有引物）; IEM/AAEMA 13.6 +/- 1.9（无引物），17.3 +/- 3.2（有引物）。此外，近似渗透系数显示出与剪切粘结强度值的显著相关性（r =+0.867，p < 0.001）。用IEM/4-Meta进行的交联剂添加研究：（a）在5-9摩尔%下，IEM聚合的凝固时间减少79%;和（B）在6摩尔%下，引发剂水平要求减少60-70%以实现相当的凝固时间，并且凝固时间减少约10%。75%对于给定的引发剂水平与选定的IEM/甲基丙烯酸酯胶粘剂system.Significance：异氰酸酯基甲基丙烯酸酯牙科胶粘剂的剪切粘结强度可以通过使用反应性底漆增强;其凝固时间和引发剂的要求可以使用二甲基丙烯酸酯交联剂改善。近似的渗透系数可以用作：牙质粘合剂系统的粘合性能的指标。(C)2000年牙科材料学院。由爱思唯尔科技有限公司出版。保留所有权利。
Objectives: (a) to de sign, formulate and evaluate prototype primers and a crosslinking agent for use with isocyanatomethacrylate-based comonomer adhesives and (b) to establish correlations between bond strength and solubility parameter differences between the adhesives and etched dentin, and the permeability coefficients of the adhesives.Methods: Equimolar mixtures of 2-isocyanatoethyl methacrylate (IEM) and a methacrylate comonomer were formulated with tri-II-butyl borane oxide (TBBO) as the free radical initiator to have cure times of 6-10 min. Shear bond strengths to dentin were determined for each adhesive mixture (n = 7) using standard testing protocols. Shear bond strengths for the three systems were also determined after application of "reactive primers" to the dentin surface. The "reactive primers" contained 10-20 parts by weight of the respective comonomer mixture and 3.5 parts by weight TBBO in acetone. Solubility parameters difference values (Delta delta) and permeability coefficients (P) were approximated for each adhesive system and correlated with shear bond strength values. Additionally, a crosslinking agent was prepared by bulk reaction of an equimolar mixture containing IEM and a methacrylate comonomer. The effects of crosslinker addition on: (a) the setting time of IEM; and (b) the setting times and initiator requirements of selected IEM/comonomer mixtures were determined.Results: Shear bond strength values (MPa): IEM/HEMA 13.6 +/- 2.0 (no primer), 20.1 +/- 2.0 (with primer); IEM/ETMA 9.3 +/- 3.3 (no primer), 20.8 +/- 8.1 (with primer); IEM/AAEMA 13.6 +/- 1.9 (no primer), 17.3 +/- 3.2 (with primer). Also, approximated permeability coefficients showed a significant correlation (r = + 0.867, p < 0.001) with shear bond strength values. Crosslinker addition studies with IEM/4-META: (a) at 5-9 mol% reduced the setting time of IEM polymerization by 79%; and (b) at 6 mol% reduced initiator level requirements 60-70% to achieve a comparable setting time, and decreased setting times by ca. 75% for a given initiator level with selected IEM/methacrylate adhesive systems.Significance: The shear bond strengths of isocyanatomethacrylate-based dental adhesives can be enhanced by using reactive primers; their setting times and initiator requirements can be improved using a dimethacrylate crosslinker. approximated permeability coefficients may be useful as:indicators of bonding performance for dentin adhesive systems. (C) 2000 Academy of Dental Materials. Published by Elsevier Science Ltd. All rights reserved.