Two-Stage Amplification of Receptors Using a Multilevel Orthogonal/Simultaneous Dynamic Combinatorial Library
Two-Stage Amplification of Receptors Using a Multilevel Orthogonal/Simultaneous Dynamic Combinatorial Library
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DOI：
10.1021/ol3027335
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发表时间：
2012-12-07
期刊：
影响因子：
5.2
通讯作者：
Furlan, Ricardo L. E.
中科院分区：
文献类型：
--
作者：
Escalante, Andrea M.;Gaston Orrillo, A.;Furlan, Ricardo L. E.
在动态组合库中顺序激活不同的可逆交换反应允许直接探索化学空间：最初通过模板选择大环支架，最后将侧链和构象约束引入到这样的支架中。
Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.