HISTAMINE CONTENT OF TICK ATTACHMENT SITES AND THE EFFECTS OF H-1 AND H-2 HISTAMINE-ANTAGONISTS ON THE EXPRESSION OF RESISTANCE
HISTAMINE CONTENT OF TICK ATTACHMENT SITES AND THE EFFECTS OF H-1 AND H-2 HISTAMINE-ANTAGONISTS ON THE EXPRESSION OF RESISTANCE
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DOI：
10.1080/00034983.1982.11687525
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
WIKEL, SK
中科院分区：
文献类型：
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作者：
WIKEL, SK
与最初致敏感染的动物相比，抗性豚鼠的安德森革螨幼虫附着部位的组胺含量显著增加。分别或同时给予对1型和2型受体具有特异性的抗组胺药物，以试图改变扁虱抵抗力的表达。单独给予1型或2型组胺受体拮抗剂不会改变耐药性反应，但同时给予1型和2型抗组胺药显著阻断耐药性的表达。所有这些治疗方案，当只在最初的感染期间给予时，都不会改变获得或随后表达的扁虱抵抗力。
The histamine content at attachment sites of Dermacentor andersoni larvae on tick-resistant guinea pigs was significantly increased compared with the histamine content of similar sites on animals given an initial, sensitizing, tick infestation. Anti-histamines with specificity for type-1 and type-2 receptors were given individually or concurrently in an attempt to alter the expression of tick resistance. Type-1 or type-2 histamine receptor antagonists given individually did not alter the resistance response, but the concurrent administration of type-1 and type-2 anti-histamines significantly blocked the expression of resistance. None of these treatment regimens, when given only during an initial infestation, altered the acquisition or subsequent expression of tick resistance.