Neural correlates of altered feedback learning in women recovered from anorexia nervosa
Neural correlates of altered feedback learning in women recovered from anorexia nervosa
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DOI：
10.1038/s41598-017-04761-y
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发表时间：
2017-07-14
影响因子：
4.6
通讯作者：
Ehrlich, Stefan
中科院分区：
文献类型：
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作者：
Ritschel, Franziska;Geisler, Daniel;Ehrlich, Stefan
神经性厌食症（AN）与过度的自我控制和改变奖励为基础的决策有关，但对潜在的神经机制知之甚少。与过度认知控制的概念相一致，我们最近发现，在概率逆转学习（PRL）任务中，急性病患者（acAN）的丢失移位试验中，背侧前扣带皮层（dACC）激活增加。然而，营养不良可能会调节大脑功能。为了从状态因素中分离特质，目前的fMRI研究调查了康复患者的认知控制（recAN）。31名recAN和31名健康对照（HC）在fMRI期间完成了PRL任务。基于以前的研究结果，我们专注于血流动力学反应，在失去转变的行为，并进行了补充功能连接分析。相对于HC，RecAN显示出升高的Lose-shift行为。在神经水平上，recAN显示正常的dACC反应，但增加额顶叶控制区的激活。在recAN中，额叶和顶叶感兴趣区域之间的耦合增加的趋势也很明显。目前recAN的研究结果与我们以前在acAN中的研究结果不同。虽然对负反馈的异常dACC反应可能与acAN中的体重不足状态相关，但recAN中的行为适应受损和认知控制区域激活升高提示神经效率改变。
Anorexia nervosa (AN) is associated with exaggerated self-control and altered reward-based decision making, but the underlying neural mechanisms are poorly understood. Consistent with the notion of excessive cognitive control, we recently found increased dorsal anterior cingulate cortex (dACC) activation in acutely ill patients (acAN) on lose-shift trials in a probabilistic reversal learning (PRL) task. However, undernutrition may modulate brain function. In attempt to disentangle trait from state factors, the current fMRI study investigated cognitive control in recovered patients (recAN). Thirty-one recAN and 31 healthy controls (HC) completed a PRL task during fMRI. Based on previous findings, we focused on hemodynamic responses during lose-shift behaviour and conducted supplementary functional connectivity analysis. RecAN showed elevated lose-shift behaviour relative to HC. On the neural level, recAN showed normal dACC responses, but increased activation in fronto-parietal control regions. A trend for increased coupling between frontal and parietal regions of interest was also evident in recAN. The current findings in recAN differ from those in our previous study in acAN. While aberrant dACC response to negative feedback may be a correlate of the underweight state in acAN, impaired behavioural adaptation and elevated activation of cognitive control regions in recAN is suggestive of altered neural efficiency.