Removal of the superior cervical ganglia fails to block Fos induction in the accessory olfactory system of male mice after exposure to female odors.
Removal of the superior cervical ganglia fails to block Fos induction in the accessory olfactory system of male mice after exposure to female odors.
复制标题
去除颈上神经节并不能阻止雄性小鼠接触雌性气味后副嗅觉系统中 Fos 的诱导。
DOI：
10.1016/s0304-3940(03)00471-3
复制
发表时间：
2003
影响因子：
2.5
通讯作者：
Cherry,JA
中科院分区：
文献类型：
--
作者：
Pankevich,D;Baum,MJ;Cherry,JA
当暴露于雌性气味时，睾丸激素引发的雄性小鼠在犁鼻器（VNO）和相关的辅助嗅觉结构中显示出强烈的立即早期基因表达。我们问是否上级颈神经节（SCG），提供自主输入的VNO，气味诱导Fos所需的。性腺完整的雄性小鼠接受假手术，单侧或双侧SCG病变，并暴露于发情期雌性的气味。在干净的床上用品相比，女性的气味显着增加神经元Fos免疫反应在整个VNO投射途径的网站，但这些反应并没有可靠的修改SCG去除。因此，去甲肾上腺素能输入的VNO，调节泵送机制，被认为是促进进入VNO腔的化学信号，是不需要的气味诱导Fos在小鼠的辅助嗅觉系统。
When exposed to female odors, testosterone-primed male mice show a robust expression of immediate early genes in the vomeronasal organ (VNO) and associated accessory olfactory structures. We asked whether the superior cervical ganglia (SCG), which provide autonomic inputs to the VNO, are required for odor induction of Fos. Gonadally intact male mice received sham, unilateral, or bilateral SCG lesions and were exposed to odors from estrous females. In comparison to clean bedding, female odors significantly increased neuronal Fos immunoreactivity in sites throughout the VNO projection pathway, but these responses were not reliably modified by SCG removal. Thus, noradrenergic inputs to the VNO, which regulate a pumping mechanism thought to facilitate entrance of chemosignals into the VNO lumen, are not required for odors to induce Fos in the mouse accessory olfactory system.