Viral infection in asthma.
Viral infection in asthma.
复制标题
DOI：
10.2332/allergolint.r-07-156
复制
发表时间：
2008-03-01
期刊：
影响因子：
--
通讯作者：
Kobayashi, Tomoko
中科院分区：
文献类型：
--
作者：
Hashimoto, Shu;Matsumoto, Ken;Kobayashi, Tomoko
在哮喘中，呼吸道病毒感染涉及以下几个问题：1)婴儿期的呼吸道病毒感染是哮喘的危险因素，并可能导致日后的哮喘发展；2)呼吸道病毒感染与哮喘的急性加重有关；以及3)糖皮质激素(GC)不足以控制呼吸道病毒感染后哮喘相关症状。呼吸道病毒感染时，多种细胞、炎症介质和细胞因子参与呼吸道炎症的产生。呼吸道上皮细胞是呼吸道病毒感染和复制的场所。它们积极参与呼吸道炎症的产生：1)它们产生各种促炎细胞因子、趋化因子和介质；2)它们经历细胞凋亡，从而损害修复过程。因此，了解支气管上皮细胞在哮喘的病理生理学中的作用是很重要的。本文就病毒感染与哮喘之间的相互作用作一综述，以阐明呼吸道上皮细胞在病毒感染中的作用。
In bronchial asthma, respiratory virus infection involves several issues: 1) respiratory virus infection in infancy is a risk factor for, and may predispose to, the development of asthma later in life; 2) respiratory virus infection is associated with the acute exacerbation of bronchial asthma; and, 3) glucocorticosteroids (GC) are not adequate for controlling asthma-related symptoms upon respiratory virus infection. Various cells, inflammatory mediators and cytokines participate in the production of airway inflammation upon respiratory virus infection. Bronchial epithelial cells are a site of infection and replication of respiratory virus. They actively participate in the production of airway inflammation: 1) they produce various proinflammatory cytokines, chemokines and mediators; and, 2) they undergo apoptosis, thereby impairing the repair process. It is therefore important to understand the role of bronchial epithelial cells in the pathophysiology of bronchial asthma. In this review, the interaction between viral infection and asthma is discussed to elucidate the role of bronchial epithelial cells in viral infection.