POSTTRAUMATIC ALZHEIMERS-DISEASE - PREPONDERANCE OF A SINGLE PLAQUE TYPE
POSTTRAUMATIC ALZHEIMERS-DISEASE - PREPONDERANCE OF A SINGLE PLAQUE TYPE
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DOI：
10.1111/j.1365-2990.1991.tb00695.x
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发表时间：
1991-02-01
影响因子：
5
通讯作者：
ROBERTS, GW
中科院分区：
文献类型：
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作者：
CLINTON, J;AMBLER, MW;ROBERTS, GW
老年痴呆症的病因尚不清楚。 已经提出了几个因素，包括头部创伤。 目前，头部损伤和随后的神经退行性过程之间的联系在很大程度上是间接的，除了在拳击手中发现的拳击员痴呆症（拳打醉酒综合征）。 最近的研究表明，患有这种综合征的拳击手的大脑含有大量的“弥漫性”β蛋白免疫反应斑块。 我们推测这种斑块类型可能与创伤引起的阿尔茨海默病样变性有关。为了验证这一假设，我们重新研究了之前报道的创伤后早发阿尔茨海默病病例。 使用淀粉样β蛋白抗体的免疫细胞化学显示大量的“弥漫性”非嗜Congophilic斑块，很少或没有神经炎成分。 在患有拳击员痴呆症的拳击手的大脑中，这种斑块类型也有类似的优势。 我们的观察结果支持创伤诱导的阿尔茨海默病样退行性过程的想法，并表明这种情况与“弥漫性”斑块的显着优势有关。
The cause of Alzheimer's disease is unknown. Several factors have been proposed including head trauma. At present, the link between head injury and a subsequent neurodegenerative process is largely circumstantial, except in the case of dementia pugilistica (punch drunk syndrome) found in boxers. Recent studies have shown that the brains of boxers with this syndrome contain large numbers of 'diffuse' beta-protein immunoreactive plaques. We supposed that this plaque type might be associated with trauma induced Alzheimer-like degeneration.In order to test this hypothesis we have re-investigated a previously reported case of post-traumatic premature Alzheimer's disease. Immunocytochemistry using antibodies to amyloid beta-protein revealed large numbers of 'diffuse' non-Congophilic plaques with little or no neuritic component. A similar preponderance of this plaque type is present in the brains of boxers with dementia pugilistica. Our observations support the idea of a trauma induced Alzheimer-like degenerative process and indicate that such a condition is associated with a marked preponderance of 'diffuse' plaques.