Electrohydrodynamic-jetting (EHD-jet) 3D-printed functionally graded scaffolds for tissue engineering applications
Electrohydrodynamic-jetting (EHD-jet) 3D-printed functionally graded scaffolds for tissue engineering applications
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DOI：
10.1557/jmr.2018.159
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发表时间：
2018-06
影响因子：
2.7
通讯作者：
S. Vijayavenkataraman;Shuo Zhang;W. Lu;J. Fuh
中科院分区：
文献类型：
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作者：
S. Vijayavenkataraman;Shuo Zhang;W. Lu;J. Fuh
仿生学是组织工程支架的理想品质。虽然文献中报道的大多数支架包含单个孔径或孔隙率，但天然生物组织（如软骨和皮肤）具有分层结构，具有特定区域的孔径和力学性能。因此，需要功能分级支架（FGS）。EHD-jet 3D打印是一种高分辨率的工艺，多种聚合物溶液可以轻松加工成3D多孔支架，克服了其他3D打印方法（SLS、立体光刻和FDM）在分辨率和材料选择方面的局限性。本文介绍了一种利用EHD-jet 3D打印技术制造多孔聚己内酯基FGS的新概念验证研究。有机形态支架，多元培养系统，界面组织工程和体外肿瘤转移模型是这些聚合物FGS的一些未来应用。
Biomimicry is a desirable quality of tissue engineering scaffolds. While most of the scaffolds reported in the literature contain a single pore size or porosity, the native biological tissues such as cartilage and skin have a layered architecture with zone-specific pore size and mechanical properties. Thus, there is a need for functionally graded scaffolds (FGS). EHD-jet 3D printing is a high-resolution process and a variety of polymer solutions can be processed into 3D porous scaffolds at ease, overcoming the limitations of other 3D printing methods (SLS, stereolithography, and FDM) in terms of resolution and limited material choice. In this paper, a novel proof of concept study on fabrication of porous polycaprolactone-based FGS by using EHD-jet 3D printing technology is presented. Organomorphic scaffolds, multiculture systems, interfacial tissue engineering, and in vitro cancer metastasis models are some of the futuristic applications of these polymeric FGS.