BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl‐G is rare in transitional cell carcinomas of the urinary bladder
BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl‐G is rare in transitional cell carcinomas of the urinary bladder
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促凋亡基因 Bad、Bmf 和 Bcl-G 的 BH3 结构域突变在膀胱移行细胞癌中罕见
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
S. Lee
中科院分区：
文献类型：
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作者：
Y. Soung;J. W. Lee;W. Park;S. Nam;Jung Young Lee;N. Yoo;S. Lee
目的：越来越多的证据表明，放松对细胞凋亡的调控有助于人类癌症的发展。BCL-2家族蛋白调控细胞内固有的细胞凋亡途径。本研究的目的是探讨促凋亡基因Bad、Bmf和BclG的BH3结构域突变可能参与膀胱癌的发生发展。方法：采用单链构象多态分析方法检测43例膀胱移行细胞癌(TCC)组织中Bad、BMF和Bc l-G基因的BH3结构域的突变。结果：膀胱移行细胞癌组织中未发现Bad、Bmf和BclG基因BH3区的体细胞突变。结论：这些基因的BH3区突变在膀胱移行细胞癌中很少见，可能与膀胱移行细胞癌的发病机制无关。
Aims: Mounting evidence indicates that deregulation of apoptosis contributes to the development of human cancers. Bcl‐2 family proteins regulate the intrinsic apoptosis pathway. The aim of this study was to explore the possibility that mutation of BH3 domain of proapoptotic Bcl‐2 genes Bad, Bmf and Bcl‐G might be involved in the development of urinary bladder cancer. Methods: We analysed the BH3 domains of Bad, Bmf and Bcl‐G genes for the detection of somatic mutations in 43 transitional cell carcinomas (TCCs) of the urinary bladder by a single strand conformation polymorphism assay in this study. Results: There was no somatic mutation of BH3 domains of Bad, Bmf and Bcl‐G genes in the TCC samples. Conclusion: The data presented here indicate that BH3 domain mutation of these genes is rare in TCCs and may not contribute to the pathogenesis of TCCs.