Optical coherence tomography: A potential tool to predict premature rupture of fetal membranes
Optical coherence tomography: A potential tool to predict premature rupture of fetal membranes
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DOI：
10.1177/0954411912468557
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发表时间：
2013-01-01
期刊：
影响因子：
1.8
通讯作者：
Artmann, Aysegul T.
中科院分区：
文献类型：
--
作者：
Micili, Serap C.;Valter, Markus;Artmann, Aysegul T.
在这项研究中解决的一个基本问题是早产预测的可行性的基础上，非接触调查的胎膜原位。虽然早产和胎膜早破的现象是众所周知的，但目前还没有用于预测的诊断工具。本研究的目的是评估光学相干断层扫描是否可用于高危妊娠的临床研究。通过光学相干断层扫描和组织学技术平行测量以下类型分娩的胎膜厚度：正常分娩、无胎膜早破的早产和足月胎膜早破的分娩。我们的研究表明，膜厚度与出生类型相关。正常分娩的胎膜在统计学上显著厚于其他两组。因此，尽管正常分娩和早产足月分娩的妊娠期几乎相等，但相应的膜厚度不同。这种差异可能与先前报道的膜中的水积聚有关。光学相干断层扫描的结果令人鼓舞，这表明该技术未来可用于预测和区分不同类型的分娩。
A fundamental question addressed in this study was the feasibility of preterm birth prediction based on a noncontact investigation of fetal membranes in situ. Although the phenomena of preterm birth and the premature rupture of the fetal membrane are well known, currently, there are no diagnostic tools for their prediction. The aim of this study was to assess whether optical coherence tomography could be used for clinical investigations of high-risk pregnancies. The thickness of fetal membranes was measured in parallel by optical coherence tomography and histological techniques for the following types of birth: normal births, preterm births without premature ruptures and births at full term with premature rupture of membrane. Our study revealed that the membrane thickness correlates with the birth type. Normal births membranes were statistically significantly thicker than those belonging to the other two groups. Thus, in spite of almost equal duration of gestation of the normal births and the births at full term with premature rupture, the corresponding membrane thicknesses differed. This difference is possibly related to previously reported water accumulation in the membranes. The optical coherence tomography results were encouraging, suggesting that this technology could be used in future to predict and distinguish between different kinds of births.