Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen
Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen
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DOI：
10.1111/j.1442-9071.2010.02294.x
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发表时间：
2010-07-01
影响因子：
4
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Iwama, Daisuke;Tsujikawa, Akitaka;Yoshimura, Nagahisa
目的：探讨黄斑区融合性玻璃膜疣患者视网膜敏感度与黄斑区形态学改变的关系。方法：回顾性分析21例（22眼）黄斑区融合性玻璃膜疣患者的临床资料。使用光谱域光学相干断层扫描，每个黄斑的6 x 6 mm区域用256个连续水平扫描进行检查。采用MicroPerimeter 1进行黄斑区的微视野检查。结果：光谱域光学相干断层扫描图像显示视网膜色素上皮（retinalpigmentepithelium，RPE）的突出与融合性玻璃疣的部位相对应。17只眼（77.3%）可见光感受器内外段连接处（IS/OS）反射线不规则。这些不规则性可见于RPE突出的区域。在视网膜完整的748个点中，510个点（68.1%）的视网膜灵敏度为14分贝或更好。然而，在具有完整IS/OS线的不规则RPE中，38.9%的点获得14分贝或更好的视网膜灵敏度，但在具有不规则IS/OS线的点中，仅15.2%的点获得14分贝或更好的视网膜灵敏度。结论：融合性玻璃膜疣常表现为视网膜功能减退的病灶区，这些病灶区与视网膜色素上皮（RPE）或视网膜色素上皮（IS/OS）的不规则性一致。
P>Purpose:To examine the relationship between retinal sensitivity and morphologic changes in the macular area of eyes with confluent soft drusen.Methods:We retrospectively reviewed the medical records of the 21 consecutive patients (22 eyes) who had confluent soft drusen in the macular area. Using spectral-domain optical coherence tomography, a 6 x 6-mm area of each macula was examined with 256 sequential horizontal scans. Microperimetry in the macular area was carried out using the Micro Perimeter 1.Results:Spectral-domain optical coherence tomography images showed that protrusion of the retinal pigment epithelium (RPE) corresponded to the site of the confluent soft drusen. In addition, irregularities of the reflective line of the junction between inner and outer segments (IS/OS) of the photoreceptors were noted in 17 (77.3%) eyes. These irregularities were seen in the area with the protrusion of RPE. At 510 (68.1%) of 748 points with an intact retina, retinal sensitivity was 14 decibels or better. However, a retinal sensitivity of 14 decibels or better was obtained at 38.9% of points in irregular RPE with an intact IS/OS line, but at only 15.2% of points with an irregular IS/OS line. The mean retinal sensitivities within the area of irregular RPE with an intact IS/OS line, or in areas with an irregular IS/OS line, respectively, were significantly lower than that of intact retina (P < 0.0001).Conclusion:Eyes with confluent soft drusen often show focal areas with reduced retinal function, areas that are consistent with irregularity of the RPE or of the IS/OS line.