Graphene oxide assists polyvinylidene fluoride scaffold to reconstruct electrical microenvironment of bone tissue
Graphene oxide assists polyvinylidene fluoride scaffold to reconstruct electrical microenvironment of bone tissue
复制标题
氧化石墨烯辅助聚偏氟乙烯支架重建骨组织电微环境
DOI：
10.1016/j.matdes.2020.108564
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发表时间：
2020-05-01
影响因子：
8.4
通讯作者：
Qian, Guowen
中科院分区：
文献类型：
--
作者：
Shuai, Cijun;Zeng, Zichao;Qian, Guowen
聚偏氟乙烯（PVDF）作为一种典型的压电聚合物，在重建骨组织电微环境方面具有很大的潜力。本研究将氧化石墨烯（GO）引入到选择性激光烧结制备的PVDF支架中，旨在通过增加β相含量来增强PVDF的压电效应。氧化石墨烯的含氧官能团可以与PVDF的氟基团形成强氢键。这种相互作用将迫使氟基团平行或垂直于聚合物链排列，从而诱导从a相到β相的转变。结果表明，与纯PVDF相比，改进β相的PVDF/0.3GO支架的最大输出电压为8.2 V，电流为101.6 nA，分别提高了82.2%和68.2%。体外细胞培养证实，增强电荷可以显著改善细胞行为。此外，支架的抗压强度提高了97.9%，抗拉强度提高了24.5%，这是由于GO增强剂与PVDF链形成了强相互作用。这些积极的结果提示该支架在骨组织工程中有可能应用。(C) 2020作者。Elsevier Ltd.出版。
Polyvinylidene fluoride (PVDF), as a typical piezoelectric polymer, has a great potential in reconstructing the electrical microenvironment of bone tissue. In present study, graphene oxide (GO) was introduced into PVDF scaffold manufactured via selective laser sintering, aiming to enhance piezoelectric effect of PVDF by increasing beta phase content. In detail, the oxygen-containing functional groups of GO could form strong hydrogen bonding with fluorine groups of PVDF. The interaction would force the fluorine groups to be arranged in parallel and perpendicular to the polymer chain, thereby inducing the transformation from a phase to beta phase. Results demonstrated that the PVDF/0.3GO scaffold with improved beta phase exhibited the maximal output voltage (similar to 8.2 V) and current (similar to 101.6 nA), which were improved by 82.2% and 68.2%, respectively, in comparison with pure PVDF. In vitro cell culture confirmed that enhanced electrical charges could significantly improve cell behavior. Moreover, the scaffold presented a 97.9% increase in compressive strength and 24.5% increase in tensile strength, which was attributed to GO reinforcements forming strong interaction with PVDF chains. These positive results suggested that the scaffold might have possible application in bone tissue engineering. (C) 2020 The Authors. Published by Elsevier Ltd.