Atypical bacterial pneumonia and asthma risk.
Atypical bacterial pneumonia and asthma risk.
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非典型细菌性肺炎和哮喘风险。
DOI：
10.1081/jas-200038477
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Martin,RichardJ
中科院分区：
文献类型：
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作者：
Sutherland,ERand;Brandorff,JenniferM;Martin,RichardJ
呼吸道感染在哮喘中的作用尚不清楚。非典型细菌肺炎支原体和肺炎衣原体存在于大约 50% 哮喘患者的下呼吸道中。这项研究检验了以下假设：由肺炎支原体或肺炎衣原体引起的早期社区获得性肺炎与哮喘患病率增加有关。 35 名有社区获得性肺炎病史的受试者（22 名由非典型细菌引起，13 名由非典型病原体引起）在肺炎发病后 7-9 年通过问卷进行评估。有典型或非典型肺炎病史的受试者表现出哮喘患病率增加。非典型细菌性肺炎受试者中当前或既往哮喘患病率为 55%，非典型细菌性肺炎受试者中哮喘患病率为 61.5%。在哮喘患病率（风险比 = 0.89；95% 置信区间 = 0.49–1.61）、当前支气管扩张剂使用 [1.18 (0.44–3.17)] 和特应性家族史 [1.18 (0.73–1.91)] 或哮喘 [1.63 (0.68–3.88)] 方面，没有显示出显着的组间差异。这些数据表明，非典型细菌性肺炎带来的哮喘风险与非典型细菌性肺炎相似。有必要进行前瞻性研究来更全面地评估非典型细菌性肺炎作为哮喘危险因素的重要性。
The role of respiratory infections in asthma is poorly understood. Atypical bacteriaMycoplasma pneumoniaeandChlamydia pneumoniaeare present in the lower airways of approximately 50% of asthmatics. This study tested the hypothesis that early life community‐acquired pneumonia caused byMycoplasma pneumoniaeorChlamydia pneumoniaeis associated with increased asthma prevalence. Thirty‐five subjects with a history of community‐acquired pneumonia (22 due to atypical bacteria, 13 due to nonatypical pathogens) were evaluated by questionnaire 7–9 years after the episode of pneumonia. Subjects with a history of either typical or atypical pneumonia demonstrated increased asthma prevalence. Current or past asthma prevalence was 55% in subjects with atypical bacterial pneumonia and 61.5% in subjects with nonatypical bacterial pneumonia. Significant between‐group differences were not demonstrated with regard to asthma prevalence (risk ratio = 0.89; 95% confidence interval = 0.49–1.61), current bronchodilator use [1.18 (0.44–3.17)], and family history of atopy [1.18 (0.73–1.91)], or asthma [1.63 (0.68–3.88)]. These data suggest that atypical bacterial pneumonia confers a risk of asthma similar to that seen with nonatypical bacterial pneumonia. Prospective studies are warranted to more fully evaluate the importance of atypical bacterial pneumonia as an asthma risk factor.