BRAIN EDEMA DURING ISCHEMIA AND AFTER RESTORATION OF BLOOD-FLOW - MEASUREMENT OF WATER, SODIUM, POTASSIUM CONTENT AND PLASMA-PROTEIN PERMEABILITY
BRAIN EDEMA DURING ISCHEMIA AND AFTER RESTORATION OF BLOOD-FLOW - MEASUREMENT OF WATER, SODIUM, POTASSIUM CONTENT AND PLASMA-PROTEIN PERMEABILITY
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DOI：
10.1161/01.str.10.5.542
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发表时间：
1979-01-01
期刊：
影响因子：
8.3
通讯作者：
INABA, Y
中科院分区：
文献类型：
--
作者：
ITO, U;OHNO, K;INABA, Y
以沙土鼠左侧大脑半球为研究对象，探讨了脑缺血时及短暂脑缺血后脑血流恢复后脑水肿的发生机制。组织干燥法测定H2O含量。用火焰光度法测Na、K离子浓度。用伽马闪烁计数器测量~(131)I[血清]白蛋白(RISA)从血液到脑实质的转运。单纯的细胞毒性水肿发生在脑缺血和脑血流恢复后的短时间内。血管源性水肿是在脑血流恢复后发生的，由于血脑屏障受损，血浆成分从血液中渗出而加速的血管源性水肿。脑缺血不到1h，脑血流量恢复，脑水肿程度明显减轻。脑血流量的恢复大大加重了脑缺血3h以上后的脑水肿。
The left cerebral hemisphere of Mongolian gerbils was used to elucidate the mechanisms of brain edema which develop during cerebral ischemia and after restoration of cerebral blood flow following temporary ischemia. H2O content was measured by the tissue-drying method. Na and K ion concentration was measured by flame photometry. Passage of 131I[serum]albumin (RISA) from blood to the cerebral parenchyma was measured on a gamma scintillation counter. Pure cytotoxic edema develops during ischemia and during a short period after restoration of cerebral blood flow. Vasogenic edema, which is accelerated by the leakage of plasma constitutents from blood due to blood-brain barrier damage, developed after restoration of the cerebral blood flow. After less than 1 h of ischemia, restoration of the cerebral blood flow drastically reduced the degree of brain edema. Restoration of the cerebral blood flow greatly worsened the brain edema following more than 3 h of ischemia.