Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) αβ+CD8+ single-positive T cells, TCRγδ+ T cells, and natural killer-type cells in human thymus
Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) αβ+CD8+ single-positive T cells, TCRγδ+ T cells, and natural killer-type cells in human thymus
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DOI：
10.1182/blood.v97.3.601
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发表时间：
2001-02-01
期刊：
影响因子：
20.3
通讯作者：
Romagnani, S
中科院分区：
文献类型：
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作者：
Romagnani, P;Annunziato, F;Romagnani, S
干扰素诱导蛋白10（IP-10），干扰素γ（米格）诱导的单核因子，和干扰素诱导的T细胞α化学引诱物（I-TAC）的强反应性被发现在上皮细胞主要定位于出生后的人胸腺的髓质。3种趋化因子共有的CXC趋化因子受体（CXCR 3）也优先在相同胸腺的髓质区域表达，似乎是4个不同群体的特性：CD 3（+）T细胞受体（TCR）α β（+）CD 8（+）单阳性（SP）T细胞，TCR γ δ（+）T细胞，自然杀伤（NK）型细胞，和CD（3+（低））CD 4（+）CD 8（+）TCR（α β +）双阳性（DP）T细胞的小亚群。IP-10、Mig和I-TAC对TCR α β（+）CCD 8（+）SP T细胞、TCR γ δ（+）T细胞和NK型细胞显示出化学引诱活性，表明它们在人胸腺淋巴细胞生成过程中在成熟胸腺细胞的不同亚群的迁移中起作用。(C)2001年，美国血液学会。
Strong reactivity for interferon-inducible protein 10 (IP-10), monokine induced by interferon gamma (Mig), and interferon-inducible T-cell alpha chemoattractant (I-TAC) was found in epithelial cells mainly localized to the medulla of postnatal human thymus. The CXC chemokine receptor common to the 3 chemokines (CXCR3) was also preferentially expressed in medullary areas of the same thymuses and appeared to be a property of 4 distinct populations: CD3(+)T-cell receptor (TCR) alpha beta (+)CD8(+) single-positive (SP)T cells, TCR gamma delta (+) T cells, natural killer (NK)-type cells, and a small subset of CD(3+(low))CD4(+)CD8(+)TCR(alpha beta+) double positive (DP) T cells. IP-10, Mig, and I-TAC showed chemoattractant activity for TCR alpha beta (+)CCD8(+) SP T cells, TCR gamma delta (+) T cells, and NK-type cells, suggesting their role in the migration of different subsets of mature thymocytes during human thymus lymphopoiesis. (C) 2001 by The American Society of Hematology.