Predictive value of combined amniotic fluid proteomic biomarkers and interleukin-6 in preterm labor with intact membranes
Predictive value of combined amniotic fluid proteomic biomarkers and interleukin-6 in preterm labor with intact membranes
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DOI：
10.1016/j.ajog.2008.12.036
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发表时间：
2009-05-01
影响因子：
9.8
通讯作者：
Gratacos, Eduard
中科院分区：
文献类型：
--
作者：
Cobo, Teresa;Palacio, Montse;Gratacos, Eduard
目的：评估蛋白质组学生物标志物和白细胞介素-6单独或联合预测羊膜内感染，早产，早产儿发病率与完整的membranes.Study设计：羊水白细胞介素-6和选定的蛋白质组学生物标志物进行了测定86例早产和完整的膜（22-36周）。评估每种标志物单独或联合应用对羊膜内感染、早产和新生儿复合发病率的预测价值。（比值比，19.5; P = .012）和蛋白质组学生物标志物（优势比，25. 2; P = .001）是羊水内感染的统计学独立预测因子，其敏感性，阳性预测值，当1个标记物存在时，假阳性率为25%、17.6%和20%，当两个标记物都检测时，假阳性率为75%、75%和4.3%。他们的组合并没有提高预测早产或新生儿morbidity.CONCLUSION：联合使用蛋白质组学生物标志物和白细胞介素-6预测羊膜内感染显示出更好的准确性比单独使用时。
OBJECTIVE: To assess proteomic biomarkers and interleukin-6 alone or in combination to predict intraamniotic infection, preterm birth, and neonatal morbidity in preterm labor with intact membranes.STUDY DESIGN: Amniotic fluid interleukin-6 and selected proteomic biomarkers were assayed from 86 patients with preterm labor and intact membranes (22-36 weeks). The predictive value of each marker alone or in combination was evaluated for intraamniotic infection, preterm birth, and neonatal composite morbidity.RESULTS: Both interleukin-6 (odds ratio, 19.5; P = .012) and proteomic biomarkers (odds ratio, 25.2; P = .001) were statistically independent predictors of intraamniotic infection with sensitivity, positive predictive value, and false-positive rates of 25%, 17.6%, and 20% when 1 marker was present and of 75%, 75%, and 4.3% when both were detected. Their combination did not improve prediction of preterm birth or neonatal morbidity.CONCLUSION: The combined use of proteomic biomarkers and interleukin-6 to predict intraamniotic infection shows better accuracy than when used alone.