Differential expression of MHC class II and B7 costimulatory molecules by microglia in rodent gliomas
Differential expression of MHC class II and B7 costimulatory molecules by microglia in rodent gliomas
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DOI：
10.1016/s0165-5728(02)00350-8
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发表时间：
2002-12-01
影响因子：
3.3
通讯作者：
Schartner, J
中科院分区：
文献类型：
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作者：
Badie, B;Bartley, B;Schartner, J
为了评估脑肿瘤中小胶质细胞和巨噬细胞的免疫功能，检测了三种啮齿动物胶质瘤模型中MHC II类和B7共刺激分子的表达。小胶质细胞和巨噬细胞占总细胞的5 - 12%，在C6和9 L肿瘤中表达B7.1和MHC II类分子，但不表达RG 2胶质瘤。有趣的是，小胶质细胞和巨噬细胞表达B7.1和MHC II类分子与C6和9 L肿瘤中肿瘤浸润淋巴细胞数量的增加相关。B7.2的表达，这是目前在小胶质细胞和巨噬细胞在正常大脑中的低水平，并没有显着改变肿瘤。有趣的是，在从颅内C6肿瘤分离小胶质细胞并培养短时间后，所有三种表面抗原的表达都增加。我们的结论是，小胶质细胞，免疫活性可能被抑制在胶质瘤和直接相关的实验性脑肿瘤的免疫原性。(C)2002 Elsevier Science B. V.保留所有权利。
To assess the immune function of microglia and macrophages in brain tumors, the expression of MHC class II and B7 costimulatory molecules in three rodent glioma models was examined. Microglia and macrophages, which accounted for 5 - 12% of total cells, expressed B7.1 and MHC class II molecules in the C6 and 9L tumors, but not RG2 gliomas. Interestingly, the expression of B7.1 and MHC class II molecules by microglia and macrophage was associated with an increase in the number of tumor-infiltrating lymphocytes in C6 and 9L tumors. B7.2 expression, which was present at low levels on microglia, and macrophages in normal brain, did not significantly change in tumors. Interestingly, the expression of all three surface antigens increased after microglia were isolated from intracranial C6 tumors and cultured for a short period of time. We conclude that microglia, immune activity may be suppressed in gliomas and directly correlates to the immunogenecity of experimental brain tumors. (C) 2002 Elsevier Science B.V. All rights reserved.