Semaphorin 3A in Ankylosing Spondylitis
Semaphorin 3A in Ankylosing Spondylitis
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DOI：
10.1016/j.jmii.2017.07.001
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发表时间：
2019-02-01
影响因子：
7.4
通讯作者：
Tsai, Chang-Youh
中科院分区：
文献类型：
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作者：
Liao, Hsien-Tzung;Lin, Yuh-Feng;Tsai, Chang-Youh
目的：检测强直性脊柱炎(AS)患者血清信号素3A(Sema 3A)水平。记录患者的人口学资料、疾病活动度、功能指数和总体评分，检测人类白细胞抗原-B27(HLAB27)，并测定血沉和C反应蛋白。结果：AS患者的SEMA3A水平高于HCS患者(3.98+/-2.57vs.1.34+/-0.48 ng/ml，P=0.013)。标准受试者工作特征(ROC)的曲线下面积(AUC)表明，Sema 3A和2 ng/ml比ESR或CRP更能预测Bath强直性脊柱炎疾病活动指数(BASDAI，>；4)。Sema 3A升高与葡萄膜炎、肖伯氏试验及间质性肺疾病有较好的相关性。AS患者在接受抗肿瘤坏死因子治疗3个月后，Sema 3A(Delta Sema 3A)的变化与疾病活动波动[Delta BASDAI、Bath强直性脊柱炎功能指数(BASFI)和Bath强直性脊柱炎-全球评分(BAS-G)]呈正相关。结论：AS患者血清Sema 3A水平升高，与Schober‘s测验呈负相关。血清Sema 3A较ESR或CRP更能反映AS患者疾病的高活动性，也是监测抗肿瘤坏死因子治疗期间疾病活动性和功能状态的良好指标。此外，Sema 3A可作为AS关节外表现的预测因子，但这需要进一步的研究才能阐明。(三)2017年，台湾微生物学会。爱思唯尔台湾有限责任公司出版。
Background/Purpose: To determine serum semaphorin 3A (Sema 3A) levels in ankylosing spondylitis (AS).Methods: Serum Sema 3A was measured in 46 AS patients and 30 healthy controls (HCs). For the patients, we recorded demographic data, disease activity, functional index & global assessment, detected human leukocyte antigen-B27 (HLA-B27), and measured erythrocyte sedimentation rate (ESR) & C-reactive protein (CRP).Results: Sema 3A was higher in AS patients than in HCs (3.98 +/- 2.57 vs. 1.34 +/- 0.48 ng/ml, p = 0.013). Area under the curve (AUC) of standard receiver operating characteristic (ROC) has suggested that Sema 3A > 2 ng/ml is better to predict the higher Bath Ankylosing Spondylitis Disease Activity Index (BASDAI, > 4) than ESR or CRP. There were good correlations between higher Sema 3A and uveitis, Schober's test, as well as interstitial lung disease. AS patients undergoing anti-tumor necrosis factor therapies for 3 months exhibited a positive correlation of change in Sema 3A (Delta Sema 3A) with disease activity fluctuation [Delta BASDAI, Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis - Global score (BAS-G)].Conclusion: Serum Sema 3A level was increased in AS patients and was inversely correlated to Schober's test. Serum Sema 3A is better as a bio-marker than ESR or CRP to correlate with high disease activity in AS patients, and it is also a good indicator for monitoring disease activity and functional status during anti-TNF treatment. Also, Sema 3A may be taken as a predictor for extra-articular presentations in AS, but this needs further study to elucidate. (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.