Polymorphisms in DNA damage response genes and head and neck cancer risk.

Polymorphisms in DNA damage response genes and head and neck cancer risk.
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DOI:
10.3109/13547501003797664
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发表时间:
2010-08
期刊:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
影响因子:
--
通讯作者:
Ragin CC
Ragin CC
中科院分区:
其他
文献类型:
--
作者:
Flores-Obando RE;Gollin SM;Ragin CC

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据报道,DNA修复基因的多态是导致头颈癌风险的因素,但研究表明结果相互矛盾。目的:阐明DNA修复基因多态性对头颈癌风险的影响。进行了包括30个病例对照研究的荟萃分析。XRCC1密码子399(仅对高加索人)、XPD Asp312Asn和XRCC1密码子194变异与头颈癌之间存在有统计学意义的关联。需要评估吸烟、酒精、HPV和种族/民族对DNA修复基因多态与头颈癌之间的关联的影响。
Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results. To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk. A meta-analysis including 30 case-control studies was performed. Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer. Assessments of the effects of smoking, alcohol, HPV and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.
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