Polymorphisms in DNA damage response genes and head and neck cancer risk.
Polymorphisms in DNA damage response genes and head and neck cancer risk.
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DOI:
10.3109/13547501003797664
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发表时间:
2010-08
期刊:
影响因子:
--
通讯作者:
Ragin CC
中科院分区:
文献类型:
--
作者:
Flores-Obando RE;Gollin SM;Ragin CC
Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results. To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk. A meta-analysis including 30 case-control studies was performed. Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer. Assessments of the effects of smoking, alcohol, HPV and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.
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