Arenaviruses other than Lassa virus
Arenaviruses other than Lassa virus
复制标题
DOI：
10.1016/s0166-3542(02)00202-4
复制
发表时间：
2003-01-01
影响因子：
7.6
通讯作者：
de Lamballerie, X
中科院分区：
文献类型：
--
作者：
Charrel, RN;de Lamballerie, X
沙粒病毒科包括23种病毒，其中5种可引起病毒性出血热，病死率约为20%。这五种病毒分别是Junin病毒、Machupo病毒、Guanarito病毒、Sabia病毒和Lassa病毒，操作这些病毒需要4级生物安全设施。它们被列入疾病控制和预防中心制定的A类病原体清单，该清单将具有最大可能对公共卫生产生不利影响和大规模伤亡的病原体分组，无论是否会遇到以恶意滥用天然或工程沙粒病毒为特征的情况。本文的目的是：(1)总结现状；（ii）提供信息，帮助预测在这种情况下可能产生的影响；（三）强调需要进行基础研究，以便开发诊断、预防和治疗工具，作为对付武器化沙粒病毒的对策。(C) 2002 Elsevier Science B.V.版权所有
The family Arenaviridae includes 23 viral species, of which 5 can cause viral hemorrhagic fevers with a case fatality rate of about 20%. These five viruses are Junin, Machupo, Guanarito, Sabia and Lassa virus, the manipulation of which requires biosafety level 4 facilities. They are included in the Category A Pathogen List established by the Center for Disease Control and Prevention that groups agents with the greatest potential for adverse public health impact and mass casualties whether a situation characterized by a ill-intentioned abuse of natural or engineered arenavirus would be encountered. The aims of this article are to (i) summarize the current situation; (ii) provide information to help anticipating the effects to be expected in such a situation; and to (iii) emphasize the need for fundamental research to allow the development of diagnostic, prevention and therapeutic tools as countermeasures to weaponized arenaviruses. (C) 2002 Elsevier Science B.V. All rights reserved.