Surface modification of functional nanoparticles for controlled drug delivery
Surface modification of functional nanoparticles for controlled drug delivery
复制标题
DOI：
10.1081/dis-120021803
复制
发表时间：
2003-01-01
影响因子：
2.2
通讯作者：
Kim, JH
中科院分区：
文献类型：
--
作者：
Choi, SW;Kim, WS;Kim, JH
表面修饰的纳米粒子作为药物载体受到了广泛的关注。天然和合成聚合物被用作制备纳米颗粒的材料，并且这些纳米颗粒的性质源于这些聚合物材料。特别地，这些纳米颗粒被改性用于特定目的。（壳）纳米颗粒的表面特性比核的表面特性更重要，因为壳层直接接触体液和器官。通常，纳米颗粒用亲水性聚合物涂覆以提供长循环和/或与功能性配体或蛋白质缀合以用于位点特异性递送。本文综述了高分子功能化纳米粒的制备方法及其在长循环、定位给药和口服给药中的应用。
Surface-modified nanoparticles have received much attention as drug carriers. Natural and synthetic polymers are used as the materials to prepare nanoparticles and the properties of these nanoparticles originate with these polymeric materials. In particular, these nanoparticles are modified for specific objectives. The surface characteristics of (shell) nanoparticles are more important than those of the core, because the shell layer directly contacts body fluids and organs. Generally, the nanoparticles are coated with hydrophilic polymer to give long circulation and/or are conjugated with functional ligands or proteins for site-specific delivery. In this review, the preparative methods and the applications of surface modification of polymeric functionalized nanoparticles for long-circulation, site-specific delivery, and oral delivery are discussed.