Screening of several H-2 congenic mouse strains identified H-2q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement
Screening of several H-2 congenic mouse strains identified H-2q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement
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DOI：
10.1016/s0165-5728(00)00360-x
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发表时间：
2000-11-01
影响因子：
3.3
通讯作者：
Harris, RA
中科院分区：
文献类型：
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作者：
Abdul-Majid, KB;Jirholt, J;Harris, RA
我们通过系统筛选一系列H-2同源B10小鼠品系，确定H-2（q）为MOG诱导EAE的易感基因型。随后研究了一系列具有不同基因背景的H-2（q）-携带菌株。DBA/1小鼠对MOG（1-125）和MOG（79-96）诱导的EAE高度易感。用MOG（1-125）和MOG（79-96）免疫在DBA/1小鼠中诱导自身反应性T细胞应答。脑组织病理学显示T细胞和巨噬细胞浸润病变伴相关脱髓鞘。使其成为人类疾病的适当模型的重要特征是对MOG的高敏感性和与多发性硬化症中所涉及的免疫显性肽区同源的免疫显性肽区的依赖性。(C)2000 Elsevier Science B. V.保留所有权利。
We identified H-2(q) as a susceptible genotype for MOG-induced EAE by systematic screening of a series of H-2 congenic B10 mouse strains. A series of H-2(q)-bearing strains with divergent gene backgrounds were subsequently investigated. DBA/1 mice were highly susceptible to MOG(1-125)- and MOG(79-96)-induced EAE in the absence of pertussis toxin. Immunisation with MOG(1-125) and MOG(79-96) induced an autoreactive T-cell response in DBA/1 mice. Brain histopathology revealed T-cell and macrophage-infiltrated lesions with associated demyelination. The important features which make this an appropriate model of human disease are high sensitivity to MOG and dependence of an immunodominant peptide region homologous to that implicated in multiple sclerosis. (C) 2000 Elsevier Science B.V. All rights reserved.