Early development of a somatosensory fovea: a head start in the cortical space race?
Early development of a somatosensory fovea: a head start in the cortical space race?
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DOI：
10.1038/85992
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发表时间：
2001-04-01
影响因子：
25
通讯作者：
Catania, KC
中科院分区：
文献类型：
--
作者：
Catania, KC
星鼻鼹鼠的每根触须周围有11个机械感觉附属物，来自单一附属物触觉中央凹的初级传入在躯体感觉皮层中的代表性大大超过。结果发现，中央凹附属器导致的发展在周边，有最大的神经支配的表面积在胚胎中，并发展成熟的神经末梢和表皮感觉器官第一，而且，在发育中的皮质，代谢活动的标记物（细胞色素氧化酶）出现在中央凹代表。这种发育顺序可能为中央凹提供了竞争皮层空间的优势，并解释了中央凹传入的皮层面积要大得多。
Star-nosed moles have 11 mechanosensory appendages surrounding each nostril, and primary afferents from a single appendage—the tactile fovea—are greatly over-represented in somatosensory cortex. It was found that the foveal appendage led development in the periphery, had the greatest innervated surface area in embryos, and developed mature nerve terminals and epidermal sensory organs first; also, in developing cortex, markers for metabolic activity (cytochrome oxidase) appeared first in the fovea representation. This developmental sequence may provide the fovea with an advantage in a competition for cortical space, and account for the much larger areas of cortex devoted to foveal afferents.