Voxel-based micro-finite element analysis of dental implants in a human cadaveric mandible: Tissue modulus assignment and sensitivity analyses
Voxel-based micro-finite element analysis of dental implants in a human cadaveric mandible: Tissue modulus assignment and sensitivity analyses
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DOI：
10.1016/j.jmbbm.2019.03.008
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发表时间：
2019-06-01
影响因子：
3.9
通讯作者：
Du, Jing
中科院分区：
文献类型：
--
作者：
Mao, Qiyuan;Su, Kangning;Du, Jing
牙种植体治疗的成功与种植体-骨相互作用的复杂三维（3D）生物力学有关。本文基于植入种植体的下颌骨标本的微X射线计算机断层扫描（micro-CT）图像建立了三维数值模型，模拟结果表明，骨中计算的应变值对骨小梁组织模量的不确定性敏感，而对种植体和牙齿的模量以及固定边界条件的几何细节不敏感。提出了一种基于骨体积分数（BV/TV）的方法，根据骨单元的BV/TV来分配骨单元的组织模量，以增加网格的连通性并提高模型的准确性。这些模型对于计算种植体载荷下的3D全场骨应变具有潜在的强大功能，可以对不同的种植体设计进行计算机测试，但需要对模型进行验证。计算结果显示，在骨-种植体接触区域，更重要的是，在不与种植体接触的颊侧（唇侧）骨中存在高应变集中。计算的应变集中模式被认为是在良好的协议，从我们以前的实验，使用3D全场力学测试加上微CT和数字体积相关的观察。颊骨比骨的其他区域更薄且刚度更小，并且也是牙科种植体治疗后通常观察到的骨吸收区域。
The success of dental implant treatment is related to the complex 3-dimensional (3D) biomechanics of the implant-bone interaction. In this work, 3D numerical models are built based on micro X-ray computed tomography (micro-CT) images of a cadaveric mandible specimen with implants placed in it. The simulation results show that the computed strain values in bone are sensitive to the uncertainties in trabecular tissue modulus and fairly insensitive to the modulus of implants and teeth and the detailed geometry of the fixed boundary condition. A bone-volume-fraction (BV/TV) based method is proposed to assign the tissue moduli of bone elements based on their BV/TV to increase the connectivity of the mesh and to improve the accuracy of the models. These models are potentially powerful for calculating the 3D full-field bone strain under implant loading, enabling in silico testing of different implant designs, but demand validation of the models. The computed results reveal high strain concentration at bone-implant contact areas and, more importantly, in the buccal (lip-side) bone that is not making contact with the implant. The computed strain concentration patterns are found to be in good agreement with the observations from our prior experiments using 3D full-field mechanical testing coupled with micro-CT and digital volume correlation. The buccal bone is thinner and less stiff than other areas of bone and is also the commonly observed area of bone resorption after dental implant treatment.