Influences of the depth-dependent material inhomogeneity of articular cartilage on the fluid pressurization in the human knee
Influences of the depth-dependent material inhomogeneity of articular cartilage on the fluid pressurization in the human knee
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DOI：
10.1016/j.medengphy.2013.05.005
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发表时间：
2013-11-01
影响因子：
2.2
通讯作者：
Li, L. P.
中科院分区：
文献类型：
--
作者：
Dabiri, Y.;Li, L. P.
关节软骨的材料特性是深度依赖性的，即它们在浅、中和深区域中不同。这种深度依赖性材料不均匀性在膝关节孔隙力学响应中的作用尚未通过患者特定关节建模进行研究。在本研究中，将深度依赖性和部位特异性材料特性纳入解剖学上精确的膝关节模型，该模型由股骨远端、股骨软骨、胫骨、胫骨软骨和胫骨近端组成。关节软骨和滑膜中的胶原纤维、蛋白多糖基质和液体被认为是不同的成分。通过有限元分析确定膝关节中的液体加压。结果表明，深度相关的不均匀性对流体增压，压应力，第一主应力和应变沿沿着组织深度的影响。深度非均匀性通过提高流体压力和降低有效压应力，增强了流体对浅部加载的支持作用。深度依赖性也降低了软骨-骨界面处的拉伸应力和应变。目前的3D建模揭示了复杂的流体加压和3D应力，其取决于机械接触和弛豫时间，这不能通过文献中的现有2D模型来预测。最大的流体压力，观察到在内侧髁，无论深度依赖性的不均匀性。结果表明，组织不均匀性在减少深部组织骨折，保护浅表组织免受过度压应力和改善关节润滑方面的作用。(C)2013年IPEM。由爱思唯尔有限公司出版。保留所有权利。
The material properties of articular cartilage are depth-dependent, i.e. they differ in the superficial, middle and deep zones. The role of this depth-dependent material inhomogeneity in the poromechanical response of the knee joint has not been investigated with patient-specific joint modeling. In the present study, the depth-dependent and site-specific material properties were incorporated in an anatomically accurate knee model that consisted of the distal femur, femoral cartilage, menisci, tibial cartilage and proximal tibia. The collagen fibers, proteoglycan matrix and fluid in articular cartilage and menisci were considered as distinct constituents. The fluid pressurization in the knee was determined with finite element analysis. The results demonstrated the influences of the depth-dependent inhomogeneity on the fluid pressurization, compressive stress, first principal stress and strain along the tissue depth. The depth-dependent inhomogeneity enhanced the fluid support to loading in the superficial zone by raising the fluid pressure and lowering the compressive effective stress at the same time. The depth-dependence also reduced the tensile stress and strain at the cartilage bone interface. The present 3D modeling revealed a complex fluid pressurization and 3D stresses that depended on the mechanical contact and relaxation time, which could not be predicted by existing 2D models from the literature. The greatest fluid pressure was observed in the medial condyle, regardless of the depth-dependent inhomogeneity. The results indicated the roles of the tissue inhomogeneity in reducing deep tissue fractures, protecting the superficial tissue from excessive compressive stress and improving the lubrication in the joint. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.