A Home-Based Exercise Program to Improve Function, Fatigue, and Sleep Quality in Patients With Stage IV Lung and Colorectal Cancer: A Randomized Controlled Trial
A Home-Based Exercise Program to Improve Function, Fatigue, and Sleep Quality in Patients With Stage IV Lung and Colorectal Cancer: A Randomized Controlled Trial
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DOI：
10.1016/j.jpainsymman.2012.05.006
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发表时间：
2013-05-01
影响因子：
4.7
通讯作者：
Basford, Jeffrey R.
中科院分区：
文献类型：
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作者：
Cheville, Andrea L.;Kollasch, Jenny;Basford, Jeffrey R.
语境。锻炼对癌症患者有益，但对家庭方法的研究，特别是对于患有 IV 期癌症的患者，仍然规模较小且处于探索性阶段。 目标。对家庭运动干预进行充分有力的试验，该干预可以轻松地融入已建立的交付和报销结构中。方法。在一项为期八周的试验中，66 名患有 IV 期肺癌或结直肠癌的成年人被随机分配接受常规护理或增量步行和家庭力量训练。锻炼的参与者在单次物理治疗就诊期间接受指导，随后每周锻炼四天或更长时间；在每两个月一次的电话会议中提出了训练和步数目标。主要结果指标是使用门诊急性护理后基本活动简表评估活动能力。次要结局包括疼痛和睡眠质量以及进行日常活动的能力（急性护理后日常活动简表）、生活质量（癌症治疗功能评估 - 一般）和疲劳（癌症治疗功能评估 - 疲劳）。结果。 3 名参与者退出，7 名参与者死亡（干预组 5 名，对照组 2 名，P = 0.28）。第 8 周时，与常规护理组相比，干预组报告活动能力（P = 0.01）、疲劳（P = 0.02）和睡眠质量（P = 0.05）有所改善，但其他指标没有差异。结论。家庭锻炼计划似乎能够改善第四期肺癌和结直肠癌患者的活动能力、疲劳程度和睡眠质量。 (C) 2013 年由 Elsevier Inc. 代表美国癌症疼痛缓解委员会发布。
Context. Exercise benefits patients with cancer, but studies of home-based approaches, particularly among those with Stage IV disease, remain small and exploratory.Objectives. To conduct an adequately powered trial of a home-based exercise intervention that can be facilely integrated into established delivery and reimbursement structures.Methods. Sixty-six adults with Stage IV lung or colorectal cancer were randomized, in an eight-week trial, to usual care or incremental walking and home-based strength training. The exercising participants were instructed during a single physiotherapy visit and subsequently exercised four days or more per week; training and step-count goals were advanced during bimonthly telephone calls. The primary outcome measure was mobility assessed with the Ambulatory Post Acute Care Basic Mobility Short Form. Secondary outcomes included ratings of pain and sleep quality as well as the ability to perform daily activities (Ambulatory Post Acute Care Daily Activities Short Form), quality of life (Functional Assessment of Cancer Therapy-General), and fatigue (Functional Assessment of Cancer Therapy-Fatigue).Results. Three participants dropped out and seven died (five in the intervention and two in the control group, P = 0.28). At Week 8, the intervention group reported improved mobility (P = 0.01), fatigue (P = 0.02), and sleep quality (P = 0.05) compared with the usual care group, but did not differ on the other measures.Conclusion. A home-based exercise program seems capable of improving the mobility, fatigue, and sleep quality of patients with Stage IV lung and colorectal cancer. (C) 2013 Published by Elsevier Inc. on behalf of U.S. Cancer Pain Relief Committee.