Ethnic differences and heritability of blood pressure circadian rhythm in African and European American youth and young adults.
Ethnic differences and heritability of blood pressure circadian rhythm in African and European American youth and young adults.
复制标题
DOI：
10.1097/hjh.0000000000002988
复制
发表时间：
2022-01-01
影响因子：
4.9
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xu Y;Su S;Brown M;Snieder H;Harshfield G;Wang X
本研究的目的是调查是否血压（BP）昼夜节律在非洲裔美国人（AAs）不同于在欧洲裔美国人（EAs）。我们进一步研究了BP昼夜节律参数的遗传和/或环境来源的方差，以及它们在多大程度上取决于种族或性别。使用傅立叶变换从760个个体（平均年龄，17.2±3.3; 322对双胞胎和116个单胞胎; 351个AA）的动态BP监测数据获得BP昼夜节律的量化。BP昼夜节律显示出明显的种族差异，AA具有较低的振幅（P=1.5e-08），较低的百分比节律（P=2.8e-11），较高的MESOR（P=2.5e-05），更可能不显示昼夜节律（P=0.002）或不同步（P=0.003）。家族聚集被确定为振幅，百分比节奏和acrophase与遗传因素和共同的环境因素一起占23%至33%的总方差的这些BP昼夜节律参数。独特的环境因素是最大的贡献者，解释高达67%-77%的总方差的这些参数。血压昼夜节律的方差分量没有观察到性别或种族差异。这项研究表明，BP昼夜节律的种族差异已经存在于青年与AA有一个阻尼的昼夜节律和更好的BP昼夜节律可能会实现环境因素的变化。
The aim of this study was to investigate whether blood pressure (BP) circadian rhythm in African Americans (AAs) differed from that in European Americans (EAs). We further examined the genetic and/or environmental sources of variances of the BP circadian rhythm parameters and the extent to which they depend on ethnicity or sex. Quantification of BP circadian rhythm was obtained using Fourier transformation from the ambulatory BP monitoring data of 760 individuals (mean age, 17.2±3.3; 322 twin pairs and 116 singletons; 351 AAs). BP circadian rhythm showed a clear difference by ethnic group with AAs having a lower amplitude (P=1.5e-08), a lower percent rhythm (P=2.8e-11), a higher MESOR (P=2.5e-05) and being more likely not to display circadian rhythm (P=0.002) or not in phase (P=0.003). Familial aggregation was identified for amplitude, percent rhythm and acrophase with genetic factors and common environmental factors together accounting for 23% to 33% of the total variance of these BP circadian rhythm parameters. Unique environmental factors were the largest contributor explaining up to 67%-77% of the total variance of these parameters. No sex or ethnicity difference in the variance components of BP circadian rhythm was observed. This study suggests that ethnic differences in BP circadian rhythm already exist in youth with AAs having a dampened circadian rhythm and better BP circadian rhythm may be achieved by changes in environmental factors.