Pallidotomy and incidental sequence learning in Parkinson's disease
Pallidotomy and incidental sequence learning in Parkinson's disease
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DOI：
10.1097/00001756-200301200-00004
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发表时间：
2003-01-20
期刊：
影响因子：
1.7
通讯作者：
Rothwell, JC
中科院分区：
文献类型：
--
作者：
Brown, RG;Jahanshahi, M;Rothwell, JC
来自动物研究和人脑成像研究的证据表明，皮质-纹状体运动回路在序列顺序信息的附带学习中发挥重要作用。到目前为止，试图通过对纹状体疾病患者的研究来解决这一问题，但结果并不确定。本研究探讨了帕金森病患者苍白球治疗性病变的影响。该病变阻断了壳核向运动皮质的初级输出，消除了相对于对照组和未手术患者的附带学习。这一发现为模型提供了支持，该模型提出纹状体内的上下文检测是串行顺序学习的中心过程。一个意想不到的影响的病变是显着减少随机刺激的反应时间相对于一个有序的系列，相反的正常模式。据推测，这可能反映了对新奇事物的无意识警觉反应，这一过程涉及腹侧纹状体及其皮质靶点。对接受功能性基底神经节手术的帕金森病患者的研究可能会进一步阐明人类串行顺序学习的机制和神经元基质。
Converging evidence from animal research and human brain imaging studies, points to an important role of cortical-striatal motor circuitry in the incidental learning of serial order information. To date, attempts to address this role through the study of patients with striatal disorder have proved inconclusive. The present study examined the impact of a therapeutic lesion of the globus palliclus in patients with Parkinson's disease. The lesion, which blocks a primary output of the putamen to the motor cortices, eliminated incidental learning relative both to controls and unoperated patients. The finding offers support for models proposing that context detection within the striatum is a central process in serial order learning. An unexpected effect of the lesion was to significantly reduce the response time to random stimuli relative to an ordered series, the opposite of the normal pattern. It is speculated that this may reflect an unconscious alerting response to novelty, a process suggested to involve the ventral striatum and its cortical targets. Research on Parkinson's disease patients undergoing functional basal ganglia surgery may shed further light on the mechanisms and neuronal substrate of serial order learning in humans.