Coats' disease.
Coats' disease.
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DOI：
10.1097/iio.0b013e3181693467
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Mukai, Shizuo
中科院分区：
文献类型：
--
作者：
Rubin, Michael P;Mukai, Shizuo
Coats’ disease was first described by George Coats1 in 1908. It is a condition of undetermined etiology characterized by telangiectatic and aneurysmal retinal vessels associated with subretinal and intraretinal exudation in otherwise healthy individuals. Coats’ disease is 3 times more prevalent in males than females. It has no known racial or ethnic association and is unilateral in at least 80% of cases. 2 The disease has been reported to occur in children as young as 4 months of age, and some speculate that there might be some manifestation of the process already at birth. The average age of diagnosis is 8 to 16 years, and among the individuals with the juvenile form of Coats’ disease, two-thirds develop clinical manifestation by the age of 10 years. Approximately one-third of patients do not present with symptoms until after the age of 30. The most common presenting complaints include decreased vision, strabismus, and leukocoria. 3, 4Coats’-like phenotype has been reported to be associated with other disease processes including retinitis pigmentosa (RP), 5 Hallermann-Streiff syndrome, 6 Turner syndrome, 7 and Senior Loken syndrome. 8 Despite these reports, there is no evidence of a definite link between these conditions and Coats’ disease.
