The mediator effect of personality traits on the relationship between childhood abuse and depressive symptoms in schizophrenia
The mediator effect of personality traits on the relationship between childhood abuse and depressive symptoms in schizophrenia
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DOI：
10.1016/j.psychres.2017.06.039
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发表时间：
2017-11-01
影响因子：
11.3
通讯作者：
Kusumi, Ichiro
中科院分区：
文献类型：
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作者：
Okubo, Ryo;Inoue, Takeshi;Kusumi, Ichiro
先前的研究表明，人格特质在重度抑郁障碍和非临床普通成人受试者的童年虐待和抑郁症状之间的关系中起到中介作用。在本研究中，我们的目的是检验人格特征在儿童期虐待和精神分裂症抑郁症状之间的关系中起中介作用的假设。我们使用以下问卷对255名门诊精神分裂症患者进行评估：儿童虐待和创伤量表、气质和性格问卷以及患者健康问卷-9。采用单因素分析、多元回归分析、结构方程建模等方法对数据进行分析。忽视与性虐待和抑郁症状的严重程度之间的关系主要是通过高伤害回避、低自我定向、低合作的人格特质来调节的。这一发现得到了逐步多元回归分析结果和扫描电子显微镜可接受的拟合指数的支持。因此，我们的结果表明，人格特征在儿童期虐待和精神分裂症抑郁症状之间的关系中起中介作用。目前的研究和我们以前的研究也表明，这种中介效应可以独立于精神障碍的存在或类型而发生。临床医生应该定期评估儿童期虐待史、人格特征及其对精神分裂症的影响。
Previous studies indicated that personality traits have a mediator effect on the relationship between childhood abuse and depressive symptoms in major depressive disorder and nonclinical general adult subjects. In the present study, we aimed to test the hypothesis that personality traits mediate the relationship between childhood abuse and depressive symptoms in schizophrenia. We used the following questionnaires to evaluate 255 outpatients with schizophrenia: the Child Abuse and Trauma Scale, temperament and character inventory, and Patients Health Questionnire-9. Univariate analysis, multiple regression analysis, and structured equation, modeling (SEM) were used to analyze the data. The relationship between neglect and sexual abuse and the severity of depressive symptoms was mostly mediated by the personality traits of high harm avoidance, low self-directedness, and low cooperativeness. This finding was supported by the results of stepwise multiple regression analysis and the acceptable fit indices of SEM. Thus, our results suggest that personality traits mediate the relationship between childhood abuse and depressive symptoms in schizophrenia. The present study and our previous studies also suggest that this mediator effect could occur independent of the presence or type of mental disorder. Clinicians should routinely assess childhood abuse history, personality traits, and their effects in schizophrenia.