A chiral rhodium complex for rapid asymmetric transfer hydrogenation of imines with high enantioselectivity.
A chiral rhodium complex for rapid asymmetric transfer hydrogenation of imines with high enantioselectivity.
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DOI：
10.1021/ol990098q
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发表时间：
1999-08
期刊：
影响因子：
5.2
通讯作者：
Jianmin Mao;David C. Baker
中科院分区：
文献类型：
--
作者：
Jianmin Mao;David C. Baker
[公式：手性铑配合物，（R）-Cp*RhCl[（1 S，2S）-p-TsNCH（C6 H5）CH（C6 H5）NH 2]发现由[Cp* RhCl 2]2和（1 S，2S）-N-对甲苯磺酰基-1，2-二苯基乙二胺[（S，S）-TsDPEN]生成的（1a，（S，S）-Cp* RhCl TsDPEN）及其对映体1b为快速、高产率，以HCO_2 H-Et_3 N共沸物为氢源，对某些杂环亚胺进行不对称转移氢化。
[formula: see text] A chiral rhodium complex, (R)-Cp*RhCl[(1S,2S)-p-TsNCH(C6H5)CH(C6H5)NH2] (1a, (S,S)-Cp*RhClTsDPEN), generated from [Cp*RhCl2]2 and (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine [(S,S)-TsDPEN], and its enantiomer 1b were found to provide superior catalysts for the rapid, high-yielding, asymmetric transfer hydrogenation of some heterocyclic imines, using an HCO2H-Et3N azeotrope as the hydrogen source.