CYCLIC ADP RIBOSE IN BETA-CELLS
CYCLIC ADP RIBOSE IN BETA-CELLS
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DOI：
10.1126/science.8211188
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发表时间：
1993-10-22
期刊：
影响因子：
56.9
通讯作者：
BERGGREN, PO
中科院分区：
文献类型：
--
作者：
ISLAM, MS;LARSSON, O;BERGGREN, PO
高浓度葡萄糖可释放胰岛微粒体中的钙离子，并可通过随后添加cADP-核糖来取消钙离子释放。他们将这归因于葡萄糖诱导的cADP-核糖的形成，而cADP-核糖无法测量。葡萄糖诱导的花生四烯酸的形成可能介导了这种钙的释放(9)。当多个动员钙离子的第二信使从一个共同的池中释放钙离子时，结果可能被错误地解释为“交叉脱敏”。在同一期的《透视》中，Antony Galione指出，“葡萄糖导致胰腺细胞[cADP-核糖浓度升高]”(10)。据我们所知，没有数据可以证实这种说法。马里兰州首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容
centration of glucose release Ca2+ from islet microsomes and abolish Ca2+ release by the subsequent additionof cADP-ribose. This they attribute to theglucose-induced formation of cADP-ribose, which could not be measured. Glucose-induced arachidonic acid formation may mediate such a Ca2+ release (9). Whenmultiple Ca2+-mobilizing second messengers release Ca2+ from a common pool, the results can mistakenly be interpreted as" cross-desensitization." In a Perspective in the same issue, Antony Galione states that" glucose induces a rise in [cADP-ribosel concentrations in pancreatic, 3 cell"(10). We know of no data to substantiate such a statement. Md. Shahidul Islam Olof Larsson Per-Olof Berggren Rolf Luft Center for Diabetes Research, Department ofEndocrinology, Karolinska Institute, Box 60 500, Karolinska Hospital, S-104 01 Stockholm, Sweden