High spatial and temporal resolution measurement of mechanical properties in hydrogels by non-contact laser excitation
High spatial and temporal resolution measurement of mechanical properties in hydrogels by non-contact laser excitation
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DOI：
10.1063/1.4964305
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发表时间：
2016-09-01
期刊：
影响因子：
1.6
通讯作者：
Maeda, S.
中科院分区：
文献类型：
--
作者：
Hosoya, N.;Terashima, Y.;Maeda, S.
凝胶作为生物材料的潜在材料受到越来越多的关注，因为它们可以表现出相似的机械性能。使用凝胶的一个障碍是它们的机械性能被缺陷显著改变，例如不均匀的交联密度分布。如果这些缺陷可以被检测到，并且可以确定凝胶中的机械性能的值和空间分布，则可以将凝胶应用于多个领域。为了实现水凝胶力学性能的高空间和时间分辨率测量，在我们的方法中，传统的接触式激发装置被替换为非接触式激发，使用激光烧蚀为输入和磁共振弹性成像测量应力波被替换为纹影法与高速相机。磁共振弹性成像是一种局部测量技术，因此需要大量时间来表征样品，并且没有足够的空间分辨率来获得凝胶的宽范围弹性系数。我们使用激光烧蚀对凝胶施加非接触脉冲激励，在凝胶内部产生应力波。利用应力波的传播速度可以确定凝胶的力学性质。(C)2016年作者。
Gels have received increased attention as potential materials for biological materials because they can exhibit similar mechanical properties. One obstacle for using gels is that their mechanical properties are significantly altered by defects, such as an inhomogeneous crosslink density distribution. If these defects could be detected and the values and spatial distributions of mechanical properties in the gel could be determined, it would be possible to apply gels for several fields. To achieve the high spatial and temporal resolution measurement of mechanical properties in hydrogels, in our method, a conventional contact excitation device is replaced with a non-contact excitation using laser ablation for the input and magnetic resonance elastography to measure stress waves is replaced with the Schlieren method with a high-speed camera. Magnetic resonance elastography is a local measurement technique, and consequently, requires a lot of time to characterize a sample, as well as does not have sufficient spatial resolution to obtain a broad range of elasticity coefficients of gels. We use laser ablation to apply non-contact impulse excitations to gels to generate stress waves inside them. We can determine mechanical properties of gels using the stresswaves' propagation velocity. (C) 2016 Author(s).