DISHEVELLED AND ARMADILLO ACT IN THE WINGLESS SIGNALING PATHWAY IN DROSOPHILA
DISHEVELLED AND ARMADILLO ACT IN THE WINGLESS SIGNALING PATHWAY IN DROSOPHILA
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DOI：
10.1038/367080a0
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发表时间：
1994-01-06
期刊：
影响因子：
64.8
通讯作者：
NUSSE, R
中科院分区：
文献类型：
--
作者：
NOORDERMEER, J;KLINGENSMITH, J;NUSSE, R
Wnt基因编码保守的分泌蛋白，在正常发育和肿瘤发生中发挥作用1，2。对Wnt基因产物的信号转导途径知之甚少。Wnt家族中最具特征的成员之一是果蝇节段极性基因wingless 3-6。我们已经研究了具有无翅表型的片段极性基因是否介导了无翅信号。我们使用了由热休克启动子控制的无翼转基因进行遗传上位性实验。我们发现，无翼通过蓬乱和螳螂来影响同源异型盒基因的表达和角质层的分化。
THE Wnt genes encode conserved secreted proteins that play a role in normal development and tumorigenesis1,2. Little is known about the signal transduction pathways of Wnt gene products. One of the best characterized Wnt family members is the Drosophila segment polarity gene wingless3-6. We have investigated whether segment polarity genes with a wingless-like phenotype mediate the wingless signal. We used a wingless transgene controlled by a heat-shock promoter for genetic epistasis experiments. We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation.