Distinct representations and theta dynamics in dorsal and ventral hippocampus.
Distinct representations and theta dynamics in dorsal and ventral hippocampus.
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DOI：
10.1523/jneurosci.4681-09.2010
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发表时间：
2010-02-03
期刊：
影响因子：
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通讯作者：
Buzsáki G
中科院分区：
文献类型：
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作者：
Royer S;Sirota A;Patel J;Buzsáki G
虽然海马的解剖，病变和成像研究表明沿着其隔颞轴的信息处理质量不同，支持这种区别的生理机制是失踪。我们发现背侧（dCA3）和最腹侧的部分（vCA3）的海马在环境表示和时间动态之间的根本差异。dCA3神经元的离散位置场均匀地覆盖测试环境的所有部分。相比之下，vCA 3神经元i）很少显示连续的二维位置场，ii）分化的开放和封闭的臂的径向迷宫，和iii）放电类似的放电模式相对于目标，在多个臂的径向迷宫和在相反的旅程在之字形迷宫。此外，theta功率和theta节律神经元的分数大幅减少腹侧相比，背侧海马。我们假设海马的隔颞轴的空间表征是逐渐减少的。这种变化与θ节律的减少和非空间信息的表达增加有关。
Although anatomical, lesion and imaging studies of the hippocampus indicate qualitatively different information processing along its septo-temporal axis, physiological mechanisms supporting such distinction are missing. We found fundamental differences between the dorsal (dCA3) and the ventral-most parts (vCA3) of the hippocampus in both environmental representation and temporal dynamics. Discrete place fields of dCA3 neurons evenly covered all parts of the testing environments. In contrast, vCA3 neurons i) rarely showed continuous two-dimensional place fields, ii) differentiated open and closed arms of a radial maze, and iii) discharged similar firing patterns with respect to the goals, both on multiple arms of a radial maze and during opposite journeys in a zig-zag maze. In addition, theta power and the fraction of theta-rhythmic neurons were substantially reduced in the ventral as compared to dorsal hippocampus. We hypothesize that the spatial representation in the septo-temporal axis of the hippocampus is progressively decreased. This change is paralleled with a reduction of theta rhythm and an increased representation of non-spatial information.