Urinary dysfunction and orthostatic hypotension in multiple system atrophy: which is the more common and earlier manifestation?
Urinary dysfunction and orthostatic hypotension in multiple system atrophy: which is the more common and earlier manifestation?
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DOI：
10.1136/jnnp.68.1.65
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发表时间：
2000-01-01
影响因子：
11
通讯作者：
Yamanishi, T
中科院分区：
文献类型：
--
作者：
Sakakibara, R;Hattori, T;Yamanishi, T
目的：排尿功能障碍和体位性低血压是多系统萎缩（MSA）的显著自主神经特征。详细的问卷调查和自主神经功能测试进行了121例MSA患者有关泌尿和心血管systems.Methods-Replies自主神经症状的问卷调查，从121例患者，包括三个临床变种;橄榄脑桥小脑萎缩（OPCA）型48，纹状体黑质变性（SND）型17，和Shy-Drager型56。尿动力学检查包括尿后残留量测定、肌电图膀胱测压和氨甲酰胆碱注射。心血管检查包括直立倾斜试验、仰卧位血浆去甲肾上腺素（NA）测定、R-R变异性（CV R-R）测定、静脉滴注NA和异丙肾上腺素。结果发现泌尿系统症状（96%）比直立症状（43%）更常见（P
Objectives-Urinary dysfunction and orthostatic hypotension are the prominent autonomic features in multiple system atrophy (MSA). A detailed questionnaire was given and autonomic function tests were performed in 121 patients with MSA concerning both urinary and cardiovascular systems.Methods-Replies to the questionnaire on autonomic symptoms were obtained from 121 patients including three clinical variants; olivopontocerebellar atrophy (OPCA) type in 48, striatonigral degeneration (SND) type in 17, and Shy-Drager type in 56. Urodynamic studies comprised measurement of postmicturition residuals, EMG cystometry, and bethanechol injection. Cardiovascular tests included head up tilt test, measurement of supine plasma noradrenaline (norepinephrine, NA), measurement of R-R variability (CV R-R), and intravenous infusions of NA and isoproterenol.Results-Urinary symptoms (96%) were found to be more common than orthostatic symptoms (43%) (p