Brain networks affected by synchronized sleep visualized by positron emission tomography
Brain networks affected by synchronized sleep visualized by positron emission tomography
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DOI：
10.1097/00004647-199807000-00001
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发表时间：
1998-07-01
影响因子：
6.3
通讯作者：
Långström, B
中科院分区：
文献类型：
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作者：
Andersson, JLR;Onoe, H;Långström, B
19名轻度睡眠不足的健康志愿者接受了(H2O)-O-15和正电子发射断层扫描（PET）的检查。扫描在受试者清醒时和入睡后进行。根据脑电图（EEG）记录回顾性地对睡眠阶段进行分级，并将扫描结果分为两组：清醒或同步睡眠。全球流量被量化，显示睡眠和清醒之间没有差异。在校正解剖结构和整体血流差异后，进行逐像素阻塞的单向方差分析（ANOVA）。z得分分布的平方和显示睡眠和清醒之间的综合差异非常显著（P < 0.00001）。z-score图像显示，睡眠期间丘脑、额叶和顶叶联合皮层的流量减少，小脑的流量增加。在校正了整体流动和阻滞效应后，对数据进行主成分（PC）分析，对所有PC得分进行多变量方差分析（MANOVA），结果显示睡眠和清醒之间存在显著差异（P = 0.00004）。主成分2和主成分5与睡眠相关，并揭示了不同的网络，包括pc2，小脑，额叶和顶叶联合皮层，pc5，丘脑。
Nineteen lightly sleep-deprived healthy volunteers were examined with (H2O)-O-15 and positron emission tomography (PET). Scanning was performed during wakefulness and after the subjects had fallen asleep. Sleep stage was graded retrospectively from electroencephalogram (EEG) recordings, and scans were divided into two groups: wakefulness or synchronized sleep. Global flow was quantified, revealing no difference between sleep and wakefulness. A pixel-by-pixel-blocked one-way analysis of variance (ANOVA) was performed after correcting for differences in anatomy and global flow. The sum of squares of the z-score distribution showed a highly significant (P < 0.00001) omnibus difference between sleep and wakefulness. The z-score images indicated decreased flow in the thalamus and the frontal and parietal association cortices and increased flow in the cerebellum during sleep. A principal component (PC) analysis was performed on data after correction for global flow and block effects, and a multivariate analysis of variance (MANOVA) on all PC scores revealed significant (P = 0.00004) differences between sleep and wakefulness. Principal component's 2 and 5 correlated to sleep and revealed distinct networks consisting of PC 2, cerebellum and frontal and parietal association cortices, and PC 5, thalamus.