Chemical constituents of Abies fabri
Chemical constituents of Abies fabri
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冷杉的化学成分
DOI：
10.1016/j.phytochem.2015.06.012
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发表时间：
2015-09-01
期刊：
影响因子：
3.8
通讯作者：
Zhang, Wei-Dong
中科院分区：
文献类型：
--
作者：
Li, Yong-Li;Gao, Yan-Xia;Zhang, Wei-Dong
从冷杉中分离到94种化合物，包括68种萜类化合物、6种木脂素、7种黄酮类化合物和13种其他化学成分。它们的结构在光谱学方法的基础上得到了阐明，其中三种未知化合物的绝对构型通过Cu-K α x射线晶体学分析得到了确定。鉴定出12种以前未报道的化合物、1种人工产物和1种潜在人工产物，包括6种三萜、4种二萜、2种倍半萜、1种木脂素和1种苯酚。23-羟基-3-oxolanosta-8,24- di烯-26,23-olide对A549和THP-1细胞的细胞毒活性较弱，IC50值分别为5.3 μ M和5.1 μ M。爱思唯尔有限公司版权所有版权所有。
Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-K alpha X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC50 values of 5.3 and 5.1 mu M, respectively. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.