Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery.
Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery.
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DOI：
10.7150/thno.19365
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发表时间：
2017
期刊：
影响因子：
12.4
通讯作者：
Zhang XH
中科院分区：
文献类型：
--
作者：
An FF;Zhang XH
生物安全性是纳米医学临床转化的首要问题。白蛋白作为人体血液中的固有成分，无免疫原性，并因其在Abraxane中的成功临床应用而受到鼓舞，已被认为是制备用于生物成像和药物递送的纳米颗粒的有前途的材料。白蛋白纳米粒的合成策略大致可分为五类：模板、纳米载体、支架、稳定剂和白蛋白-聚合物偶联物。这篇综述介绍了利用白蛋白制备纳米颗粒的方法，从而为科学家提供了基于白蛋白的纳米医学目标驱动设计的知识。
Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.