Utilization of Host Cell Chromosome Conformation by Viral Pathogens: Knowing When to Hold and When to Fold.
Utilization of Host Cell Chromosome Conformation by Viral Pathogens: Knowing When to Hold and When to Fold.
复制标题
通过病毒病原体对宿主细胞染色体构象的利用：知道何时保持和何时折叠。
DOI：
10.3389/fimmu.2021.633762
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发表时间：
2021
影响因子：
7.3
通讯作者：
Morales AJ
中科院分区：
文献类型：
--
作者：
Majumder K;Morales AJ
虽然病毒有自己的基因组，但许多病毒的复制和生存依赖于宿主的核环境。因此，大量的工作致力于了解病毒和真核生物基因组如何相互作用。染色体构象捕获技术的最新进展提供了前所未有的机会来可视化哺乳动物基因组是如何组织的，并由此扩展到核DNA的包装如何影响细胞过程。最近的研究表明，一些病毒在进入宿主细胞核后，会产生改变宿主染色质拓扑结构的因子，从而影响宿主基因组的三维组织。此外，各种不同的病毒利用宿主基因组结构因子来推进其生命周期的各个方面。事实上，以在B淋巴细胞中建立长期潜伏感染库而闻名的人类伽玛疱疹病毒，利用基因组折叠的3D原理来包装其DNA并在宿主细胞中建立潜伏性。潜伏病毒基因组对宿主表观遗传机制的操纵在病原学上与B细胞癌变的发生有关。相比之下，小的DNA病毒被拴在支持病毒表达和复制的不同细胞位点上。在这里，我们简要回顾了病毒和宿主基因组如何在空间上交流的最新发现，以及这如何影响病毒诱导的病理。
Though viruses have their own genomes, many depend on the nuclear environment of their hosts for replication and survival. A substantial body of work has therefore been devoted to understanding how viral and eukaryotic genomes interact. Recent advances in chromosome conformation capture technologies have provided unprecedented opportunities to visualize how mammalian genomes are organized and, by extension, how packaging of nuclear DNA impacts cellular processes. Recent studies have indicated that some viruses, upon entry into host cell nuclei, produce factors that alter host chromatin topology, and thus, impact the 3D organization of the host genome. Additionally, a variety of distinct viruses utilize host genome architectural factors to advance various aspects of their life cycles. Indeed, human gammaherpesviruses, known for establishing long-term reservoirs of latent infection in B lymphocytes, utilize 3D principles of genome folding to package their DNA and establish latency in host cells. This manipulation of host epigenetic machinery by latent viral genomes is etiologically linked to the onset of B cell oncogenesis. Small DNA viruses, by contrast, are tethered to distinct cellular sites that support virus expression and replication. Here, we briefly review the recent findings on how viruses and host genomes spatially communicate, and how this impacts virus-induced pathology.
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DOI：
10.3390/v12121368
发表时间：
2020-11-30
期刊：
Viruses
影响因子：
--
作者：
Boftsi M;Majumder K;Burger LR;Pintel DJ
通讯作者：
Pintel DJ
影响因子：
10.5
作者：
Denker A;de Laat W
通讯作者：
de Laat W
影响因子：
64.5
作者：
Barlow JH;Faryabi RB;Callén E;Wong N;Malhowski A;Chen HT;Gutierrez-Cruz G;Sun HW;McKinnon P;Wright G;Casellas R;Robbiani DF;Staudt L;Fernandez-Capetillo O;Nussenzweig A
通讯作者：
Nussenzweig A
影响因子：
5.4
作者：
Evans, JD;Hearing, P
通讯作者：
Hearing, P
影响因子：
5.4
作者：
Chen, Horng-Shen;Wikramasinghe, Priyankara;Lieberman, Paul M.
通讯作者：
Lieberman, Paul M.