PHARMACOKINETICS AND BIOAVAILABILITY OF TRANEXAMIC ACID
PHARMACOKINETICS AND BIOAVAILABILITY OF TRANEXAMIC ACID
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DOI：
10.1007/bf00554669
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发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
VESSMAN, J
中科院分区：
文献类型：
--
作者：
PILBRANT, A;SCHANNONG, M;VESSMAN, J
氨甲环酸1g静脉滴注。给3名健康志愿者。血药浓度呈3个单指数期下降。大部分消除发生在前8小时，明显的消除半衰期为.apprx。血浆清除率在110~116ml/min之间。氨甲环酸尿液回收率超过95%。10名健康志愿者空腹口服氨甲环酸2g，同时进餐。食物对氨甲环酸的吸收有影响，通过比较血药浓度、达峰时间、0~6h的血药浓度曲线下面积[AUC]和尿排出量来判断。氨甲环酸的口服生物利用度，由口服和静脉注射后24小时尿排泄量计算。给药，是剂量的34%。
Tranexamic acid 1 g was given i.v. to 3 healthy volunteers. Plasma concentrations decayed in 3 monoexponential phases. Most elimination took place during the first 8 h, giving an apparent elimination half-life of .apprx. 2 h. Plasma clearance ranged between 110-116 ml/min. The urinary recovery of tranexamic acid exceeded 95% of the dose. Ten healthy volunteers were given tranexamic acid 2 g orally on an empty stomach and together with a meal. Food had an influence on the absorption of tranexamic acid, as judged by comparison of the peak plasma concentration, the time required to reach the peak, the AUC [area under the concentration time curve] from 0-6 h and the urinary excretion data. The oral bioavailability of tranexamic acid, calculated from 24 h urinary excretion after oral and i.v. administration, was 34% of the dose.