Formal synthesis of salinosporamide A using a nickel-catalyzed reductive aldol cyclization-lactonization as a key step

Formal synthesis of salinosporamide A using a nickel-catalyzed reductive aldol cyclization-lactonization as a key step
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DOI：
10.1016/j.tet.2008.06.038
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发表时间：
2008-08-18
期刊：
TETRAHEDRON
影响因子：
2.1
通讯作者：
Lam, Hon Wai
Lam, Hon Wai
中科院分区：
化学3区
文献类型：
--
作者：
Margalef, Isabel Villanueva;Rupnicki, Leszek;Lam, Hon Wai

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本文介绍了镍催化的还原羟醛环化-内酯化反应在20 S蛋白酶体抑制剂和抗癌化合物salinsporamide A的短式合成中的应用。(C)2008爱思唯尔有限公司保留所有权利。
Application of a sequential nickel-catalyzed reductive aldol cyclization-lactonization reaction in a short formal synthesis of salinsporamide A, a potent 20S proteasome inhibitor and anti-cancer compound, is described. (C) 2008 Elsevier Ltd. All rights reserved.