The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein
The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein
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DOI：
10.1016/s0014-5793(00)01289-8
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发表时间：
2000-03-17
期刊：
影响因子：
3.5
通讯作者：
Gmeiner, BMK
中科院分区：
文献类型：
--
作者：
Exner, M;Hermann, M;Gmeiner, BMK
葡萄糖衍生的自由基对低密度脂蛋白的氧化可能在糖尿病动脉粥样硬化的发病机制中起一定作用。水杨酸盐被证明能清除某些自由基。本研究测试了阿司匹林、水杨酸盐及其代谢物2，5-和2，3-二羟基苯甲酸(DHBA)对葡萄糖氧化低密度脂蛋白(LDL)的影响。只有DHBA衍生物，当存在于低密度脂蛋白修饰时，抑制低密度脂蛋白氧化和葡萄糖氧化低密度脂蛋白诱导的内皮组织因子合成的增加。DHEA不影响低密度脂蛋白的糖基化反应，DHBA的抗氧化作用可能归因于自由基清除和/或螯合过渡金属离子催化葡萄糖自氧化，(C)2000欧洲生化学会联合会。
Oxidation of low density lipoprotein (LDL) by glucose-derived radicals may play a role in the aetiology of atherosclerosis in diabetes. Salicylate was shown to scavenge certain radicals. In the present study, aspirin, salicylate and its metabolites 2,5- and 2,3-dihydroxybenzoic acid (DHBA) were tested for their ability to impair LDL oxidation by glucose. Only the DHBA derivatives, when present during LDL modification, inhibited LDL oxidation and the increase in endothelial tissue factor synthesis induced by glucose oxidised LDL. The LDL glycation reaction was not affected by DHEA, The antioxidative action of DHBA may be attributed to free radical scavenging and/or chelation of transition metal ions catalysing glucose autoxidation, (C) 2000 Federation of European Biochemical Societies.