Age-dependent susceptibility to severe disease with primary exposure to Plasmodium falciparum
Age-dependent susceptibility to severe disease with primary exposure to Plasmodium falciparum
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DOI：
10.1086/517482
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发表时间：
1998-08-01
影响因子：
6.4
通讯作者：
Hoffman, SL
中科院分区：
文献类型：
--
作者：
Baird, JK;Masbar, S;Hoffman, SL
本研究调查了印度尼西亚伊里安查亚的非免疫儿童和成人初次接触恶性疟原虫后严重疾病的发病率。到达后4个月，恶性疟原虫的横断面患病率为72%，疟疾临床诊断的月累积发病率为81%。谵妄或无意识促使被送往医院。对临床诊断为疟疾的人进行紧急疏散的记录显示，（>15岁）第3个月为1.34起事件/人年，而儿童的发生率保持稳定，约为0.25起事件/人年（相对风险= 4.51，95%置信区间[CI] = 1.94-11），在暴露的前6个月，23.2%的成年人被疏散到医院诊断为疟疾，而8.6%的儿童（相对风险= 2.7，95% CI = 1.9-3.8）。在婴儿或老年人相对较少的人群中，初次接触恶性疟原虫后患严重疾病的风险随年龄增加而增加。
This study investigated the incidence of severe disease following primary exposure to Plasmodium falciparum by nonimmune children and adults in Irian Jaya, Indonesia. Four months after arrival, the cross-sectional prevalence of P, falciparum was 72%, and the monthly cumulative incidence of clinical diagnoses of malaria was 81%. Delirium or unconsciousness prompted evacuation to the hospital. Records of emergency evacuation of persons with a clinical diagnosis of malaria revealed an incidence density among adults (>15 years) of 1.34 events/person-year in the third month, whereas the rate in children remained stable at similar to 0.25 events/person-year (relative risk = 4.51, 95% confidence interval [CI] = 1.94-11), Through the first 6 months of exposure, 23.2% of adults were evacuated to the hospital with a diagnosis of malaria compared with 8.6% of children (relative risk = 2.7, 95% CI = 1.9-3.8). In this population with relatively few infants or people of advanced age, the risk of severe disease following primary exposure to P. falciparum increased with age.