Guanfacine, but not clonidine, improves planning and working memory performance in humans
Guanfacine, but not clonidine, improves planning and working memory performance in humans
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DOI：
10.1016/s0893-133x(98)00127-4
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发表时间：
1999-05-01
影响因子：
7.6
通讯作者：
Riekkinen, P
中科院分区：
文献类型：
--
作者：
Jäkälä, P;Riekkinen, M;Riekkinen, P
本研究采用双盲、安慰剂对照设计，比较了两种α 2-受体激动剂可乐定（0.5、2和5 μ g/kg）和胍法辛（7和29 μ g/kg）对空间工作记忆、计划和注意力转移的影响，这些分数被认为依赖于前额叶皮层的“中央执行”。可乐定和胍法辛对血压和镇静的主观感觉的影响相同。0.5 μ g/kg和5 μ g/kg剂量的可乐定破坏空间工作记忆，但中等剂量没有影响。0.5和2 μ g/kg剂量的可乐定增加了计划试验中的脉冲反应。5 μ g/kg剂量的可乐定减缓了计划和注意力转移测试的努力水平。29 μ g/kg剂量的胍法辛改善了空间工作记忆和规划。胍法辛对注意定势转移无影响。这些数据表明，胍法辛改善规划和空间工作记忆，但可乐定剂量依赖性地破坏性能。胍法辛对α 2A亚型的更高选择性可能是其与可乐定差异的基础。(C)1999年美国神经精神药理学学会。出版社：Elsevier Science Inc.
The present study compares, using a double-blind, placebo controlled design the effects of two alpha 2-agonists, clonidine (0.5, 2, and 5 mu g/kg) and guanfacine (7 and 29 mu g/kg) on spatial working memory, planning and attentional set-shiffing, fractions thought to be dependent on the "central executive" of the prefrontal cortex. Blood pressure and the subjective feeling of sedation were affected equally by clonidine and guanfacine. The 0.5 mu g/kg and 5 mu g/kg doses of clonidine disrupted spatial working memory, but the medium dose had no effect. The 0.5 and 2 mu g/kg doses of clonidine increased impulsive responding in the planning test. The 5 mu g/kg dose of clonidine slowed responding at effortful levels of planning and attentional set-shifting tests. The 29 mu g/kg dose of guanfacine improved spatial working memory and planning. Guanfacine had no effect on attentional set-shifting. These data indicate that guanfacine improved planning and spatial working memory, but clonidine dose-dependently disrupted performance. It is possible that the greater selectivity of guanfacine for alpha 2A-subtype may underlie its differences from clonidine. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.