Passive mechanical properties of maturing extensor digitorum longus are not affected by lack of dystrophin.
Passive mechanical properties of maturing extensor digitorum longus are not affected by lack of dystrophin.
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成熟的趾长伸肌的被动机械特性不受抗肌营养不良蛋白缺乏的影响。
DOI：
10.1002/mus.20588
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Grange,RobertW
中科院分区：
文献类型：
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作者：
Wolff,AndrewV;Niday,AshleyK;Voelker,KevinA;Call,JarrodA;Evans,NicholasP;Granata,KevinP;Grange,RobertW
骨骼肌的机械无力被认为与杜氏肌营养不良症的发病和早期进展有关，但这一点尚未得到系统的评估。本研究的目的是在小鼠中确定：(1)成熟营养不良（mdx）肌肉的被动力学性能是否与对照组不同；(2)如果不同，则在成熟过程中这些特性发生变化的时间。在营养不良过程明显发生之前和之后（14-35天），对照和营养不良的指长伸肌（EDL）肌肉在体外接受两种被动拉伸方案（5%瞬时应变和1.5L0/s应变速率）。力分布拟合到粘弹性肌肉模型，以确定刚度和阻尼。在每个年龄阶段，他们和对照组的EDL肌肉表现出相似的被动力学特性，这表明营养不良肌肉有一个功能阈值，低于这个阈值损伤可能最小。确定这一阈值可能对涉及体力活动的肌肉萎缩症的治疗具有重要的临床意义。肌肉神经，2006
Mechanical weakness of skeletal muscle is thought to contribute to onset and early progression of Duchenne muscular dystrophy, but this has not been systematically assessed. The purpose of this study was to determine in mice: (1) whether the passive mechanical properties of maturing dystrophic (mdx) muscles were different from control; and (2) if different, the time during maturation when these properties change. Prior to and following the overt onset of the dystrophic process (14–35 days), control and dystrophic extensor digitorum longus (EDL) muscles were subjected to two passive stretch protocols in vitro (5% strain at instantaneous and 1.5L0/s strain rates). Force profiles were fit to a viscoelastic muscle model to determine stiffness and damping. Themdxand control EDL muscles exhibited similar passive mechanical properties at each age, suggesting a functional threshold for dystrophic muscle below which damage may be minimized. Determining this threshold may have important clinical implications for treatments of muscular dystrophy involving physical activity. Muscle Nerve, 2006