CVD for the Facile Synthesis of Hybrid Nanobiomaterials Integrating Functional Supramolecular Assemblies
CVD for the Facile Synthesis of Hybrid Nanobiomaterials Integrating Functional Supramolecular Assemblies
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DOI：
10.1021/la903475d
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发表时间：
2009-12-01
期刊：
影响因子：
3.9
通讯作者：
Lopez, Gabriel P.
中科院分区：
文献类型：
--
作者：
Gupta, Gautam;Rathod, Shailendra B.;Lopez, Gabriel P.
在这封信中，我们提出了一种简单的一步，通用的，可扩展的基于化学气相沉积（CVD）的工艺，用于包封和稳定一系列单组分或多组分超分子组件（原胶质体，微泡，脂质双层，光合天线复合物和其他生物材料），以形成功能混合纳米生物材料。在每种情况下，都有可能(i)形成可控的薄二氧化硅层或凝胶，使超分子组装随着时间的推移和在不利的环境条件下得以保存；（ii）调整硅胶的结构，以优化溶质可及性，同时保持被封装磷脂组装的功能动态特性。通过在室温下控制前体传递，该过程可以精确地控制二氧化硅聚合动力学的时间和空间，并且不需要或产生高浓度的有害化学物质，从而损害生物分子组装的功能；它也不需要添加剂。该工艺不同于传统的溶胶-凝胶工艺，因为它不涉及使用助溶剂（醇）和催化剂（酸或碱）。
In this letter, we present a simple one-step, versatile, scalable chemical vapor deposition (CVD)-based process for the encapsulation and stabilization of a host of single or multicomponent supramolecular assemblies (protcoliposomes, microbubbles, lipid bilayers, and photosynthetic antennae complexes and other biological materials) to form functional hybrid nanobiomaterials. In each case, it is possible (i) to form thin silica layers or gels controllably that enable the preservation of the supramolecular assembly over time and under adverse environmental conditions and (ii) to tune the structure of the silica gels so as to optimize solute accessibility while at the same time preserving functional dynamic properties of the encapsulated phospholipid assembly. The process allows precise temporal and spatial control of silica polymerization kinetics through the control of precursor delivery at room temperature and does not require or produce high concentrations of injurious chemicals that can compromise the function of biomolecular assemblies; it also does not require additives. This process differs from the conventional sol-gel process in that it does not involve the use of cosolvents (alcohols) and catalysts (acid or base).