EPISODIC LUTEINIZING-HORMONE (LH) SECRETION AND THE RESPONSE OF LH AND FOLLICLE-STIMULATING-HORMONE TO LH-RELEASING HORMONE IN AGED MEN - EVIDENCE FOR COEXISTENT PRIMARY TESTICULAR INSUFFICIENCY AND AN IMPAIRMENT IN GONADOTROPIN-SECRETION
EPISODIC LUTEINIZING-HORMONE (LH) SECRETION AND THE RESPONSE OF LH AND FOLLICLE-STIMULATING-HORMONE TO LH-RELEASING HORMONE IN AGED MEN - EVIDENCE FOR COEXISTENT PRIMARY TESTICULAR INSUFFICIENCY AND AN IMPAIRMENT IN GONADOTROPIN-SECRETION
复制标题
DOI：
10.1210/jcem-55-3-560
复制
发表时间：
1982-01-01
影响因子：
5.8
通讯作者：
TROEN, P
中科院分区：
文献类型：
--
作者：
WINTERS, SJ;TROEN, P
在14名年龄65-80岁的健康男性中研究了年龄对LH（促黄体生成激素）分泌以及LHRH给药后LH和FSH释放的影响。与年轻男性相比，平均早晨血清睾酮水平降低了16%（P < 0.05），血清LH和FSH浓度分别增加了近2倍和3倍（P < 0.01）。LH分泌事件是明显的，并没有显着差异，无论是振幅或频率从年轻男子尽管较高的平均LH浓度。老年人和年轻人在LHRH后血清LH和FSH水平的增加以及反应曲线下面积相似。然而，LH峰值反应的时间随着年龄的增长而显著延迟（P < 0.001），这表明可释放LH池的控制发生了变化。此外，老年男性LH水平在峰值后下降较慢（P < 0.01），表明LHRH刺激后激素分泌延长。这些变化与老年男性LH基础分泌过多无关，因为原发性性腺功能衰竭的年轻男性与健康年轻男性的反应没有差异（P =不显著）。LH分子大小的增加导致其清除率降低的可能性不被年轻和老年男性的基础和LHRH后血清中LH的类似Sephadex G-100洗脱曲线所支持。由于原发性睾丸功能不全，健康老年男性的间质细胞功能明显受损。这些研究进一步揭示了与衰老过程相关的下丘脑-垂体促性腺激素分泌障碍的存在。
The influence of aging on episodic LH [luteinizing hormone] secretion and the release of LH and FSH after LHRH administration was studied in 14 healthy men, aged 65-80 yr. Mean morning serum testosterone levels were reduced by 16% (P < 0.05) and serum LH and FSH concentrations were increased by nearly 2- and 3-fold, respectively (P < 0.01), compared to levels in young men. LH secretory episodes were evident and did not differ significantly in either amplitude or frequency from those of young men in spite of the higher mean LH concentrations. The increments in serum LH and FSH levels after LHRH and the areas under the response curves were similar in aged and young men. However, the time of the peak LH response was significantly delayed with aging (P < 0.001), suggesting an alteration in the control of the releasable LH pool. Further, LH levels were slower to fall after the peak in elderly men (P < 0.01), suggesting prolonged secretion of hormone after LHRH stimulation. These changes did not relate to the basal hypersecretion of LH in elderly men, as the responses in young men with primary gonadal failure did not differ from those in healthy young men (P = not significant). The possibility that increased LH molecular size leads to its reduced clearance was not supported by the similar Sephadex G-100 elution profiles for LH in both basal and post-LHRH sera from young and old men. Leydig cell function apparently is impaired in healthy elderly men as a result of primary testicular insufficiency. These studies further reveal the presence of an additional hypothalamic-pituitary disorder of gonadotropin secretion associated with the aging process.