Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
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DOI：
10.1016/j.jaci.2010.11.050
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发表时间：
2011-03-01
影响因子：
14.2
通讯作者：
Akdis, Cezmi A.
中科院分区：
文献类型：
--
作者：
Akdis, Muebeccel;Burgler, Simone;Akdis, Cezmi A.
加深我们对过敏、哮喘、自身免疫性疾病、肿瘤发展、器官移植和慢性感染的免疫调节机制的了解可能会带来有效的靶向治疗。免疫和炎症细胞的亚群通过IL和IFN相互作用; T-H和调节性T细胞以及B细胞亚群之间的相互调节和平衡为免疫干预提供了机会。在这里，我们回顾目前的知识IL 1至37和IFN-γ。自从单核细胞IL（称为IL-1）和淋巴细胞IL（称为IL-2）的发现以来，我们对IL的作用的理解大大增加;现在有超过40种细胞因子被指定为IL。对这些细胞因子或其受体表达改变的转基因或基因敲除小鼠的研究以及对编码这些产物的人类基因中的突变和多态性的分析提供了关于IL和IFN功能的重要信息。我们讨论了它们的信号通路，细胞来源，靶点，在免疫调节和细胞网络中的作用，在过敏和哮喘中的作用，以及在防御感染中的作用。（J Allergy Clin Immunol 2011;127：701-21.）
Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among T-H and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-gamma. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections. (J Allergy Clin Immunol 2011;127:701-21.)